PRSS16 - serine protease 16 Gene

Homo sapiens

Also known as TSSP

Gene ID: 10279 | Gene type: protein coding

About PRSS16

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,247,701-27,256,620 (from NCBI)

This gene has 20 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 6.8), stomach (RPKM 3.4) and 17 other tissues.

Summary

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

PRSS16 Products(1)

mRNA	Protein	Name
NM_005865.4	NP_005856.1	thymus-specific serine protease

PRSS16 Protein Structure

Peptidase_S28

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

thymus-specific serine protease

protease, serine 16

Related Diseases

Diseases

Alias

Capillariasis

Capillaria Infection	Enoplida Infections
Capillariasis Nos	Capillariosis

Pulmonary Embolism And Infarction

Sparganosis

Infection By Sparganum	Larval Diphyllobothriasis
Spirometrosis	Infection By Spirometra Larvae
Larval Dibothriocephaliasis	Sparganosis - Larval Diphyllobothriasis
Spirometriosis	Larval Dibothriocephalus Infestation
Larval Diphyllobothrium Infestation	Larval Dibothriocephalus
Infection Due To Sparganum	Larval Fish Tapeworm Infection
Spirometra Larvae Infestation	Sparganum Infestation
Larval Bothriocephalus Infestation

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Thymic Dysplasia

Paragonimiasis

Infection By Paragonimus	Lung Fluke Disease
Lung Fluke Infection	Pulmonary Paragonimiasis
Paragonimus Westermani Infection	Pulmonary Distomiasis
Parasitic Haemoptysis	Oriental Lung Fluke Disease
Endemic Haemoptysis	Paragonimosis
Pulmonary Distomatosis	Lung Fluke Disorder
Infestation By Paragonimus	Infection Due To Paragonimus Species
Infestation Due To Paragonimus Species	Oriental Lung Fluke Infestation
Endemic Oriental Haemoptysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11247	PRSS16 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRSS16	MGD	MGI:1859181
Bos taurus	PRSS16	VGNC	VGNC:33414
Canis familiaris	PRSS16	VGNC	VGNC:45063
Rattus norvegicus	PRSS16	RGD	RGD:1306652
Felis catus	PRSS16	VGNC	VGNC:69090
Macaca mulatta	PRSS16	VGNC	VGNC:82214

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