2. Gene
  3. Synj1 - synaptojanin 1 Gene

Synj1 - synaptojanin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA0910; A930006D20Rik

Gene ID: 104015 | Gene type: protein coding

About Synj1

Summary

Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic neurotransmitter receptor internalization; and synaptic vesicle uncoating. Acts upstream of or within several processes, including dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Located in Schaffer collateral - CA1 synapse and glutamatergic synapse. Part of membrane coat. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]

Synj1 Products(19)

mRNA Protein Name
NM_001045515.2 NP_001038980.1 synaptojanin-1 isoform b
NM_001164483.2 NP_001157955.1 synaptojanin-1 isoform a
NM_001405392.1 NP_001392321.1 synaptojanin-1 isoform c
NM_001405393.1 NP_001392322.1 synaptojanin-1 isoform d
NM_001405394.1 NP_001392323.1 synaptojanin-1 isoform e
NM_001405395.1 NP_001392324.1 synaptojanin-1 isoform f
NM_001405396.1 NP_001392325.1 synaptojanin-1 isoform g
NM_001405397.1 NP_001392326.1 synaptojanin-1 isoform h
NM_001405399.1 NP_001392328.1 synaptojanin-1 isoform i
NM_001405400.1 NP_001392329.1 synaptojanin-1 isoform j
NM_001405401.1 NP_001392330.1 synaptojanin-1 isoform k
NM_001405402.1 NP_001392331.1 synaptojanin-1 isoform l
NM_001405403.1 NP_001392332.1 synaptojanin-1 isoform m
NM_001405404.1 NP_001392333.1 synaptojanin-1 isoform n
NM_001405405.1 NP_001392334.1 synaptojanin-1 isoform o
NM_001405406.1 NP_001392335.1 synaptojanin-1 isoform p
NM_001405407.1 NP_001392336.1 synaptojanin-1 isoform q
NM_001405408.1 NP_001392337.1 synaptojanin-1 isoform r
NM_001405410.1 NP_001392339.1 synaptojanin-1 isoform s
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol phosphate 5-phosphatase activity IMP
IMP: Inferred from mutant phenotype
18093523 MGI
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
IMP: Inferred from mutant phenotype
18591654 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18093523 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
18591654 MGI
acts upstream of or within neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
10535736 MGI
acts upstream of or within phosphatidylinositol dephosphorylation IMP
IMP: Inferred from mutant phenotype
10535736 MGI
acts upstream of or within phosphatidylinositol metabolic process IMP
IMP: Inferred from mutant phenotype
10535736 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
18987319 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
18987319 MGI
acts upstream of or within synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18093523 MGI
acts upstream of or within synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
12481038 MGI
acts upstream of or within synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
10535736 MGI
involved in synaptic vesicle uncoating IDA
IDA: Inferred from direct assay
10535736 MGI
acts upstream of or within synaptic vesicle uncoating IMP
IMP: Inferred from mutant phenotype
12481038 MGI
involved in synaptic vesicle uncoating IMP
IMP: Inferred from mutant phenotype
10535736 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10535736 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
10535736 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18987319 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18987319 MGI
part of membrane coat IDA
IDA: Inferred from direct assay
11879655 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptojanin-1

synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14093 SYNJ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Synj1 NCBI NCBI:8867