Synpo - synaptopodin Gene

Also Known as 9130229N11; 9030217H17Rik; 9330140I15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 104027

Summary

Enables actin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament bundle assembly; and spine apparatus assembly. Located in several cellular components, including Schaffer collateral - CA1 synapse; spine apparatus; and stress fiber. Is active in glutamatergic synapse. Is expressed in several structures, including genitourinary system; respiratory system; sensory organ; skeleton; and tooth. Orthologous to human SYNPO (synaptopodin). [provided by Alliance of Genome Resources, Apr 2022]

Synpo Products (2)

mRNA	Protein	Name
NM_001109975.1	NP_001103445.1	synaptopodin isoform B
NM_177340.2	NP_796314.2	synaptopodin isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	9314539	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	37651441	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	15841212	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12928494	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12928494	MGI
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	12928494	MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	25164660	MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	25164660	MGI
involved in regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	15841212	MGI
involved in spine apparatus assembly	IMP IMP: Inferred from mutant phenotype	12928494	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	12928494	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	12928494	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	12928494	MGI
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	9314539	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	25071083	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12928494	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12928494	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	15841212	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synaptopodin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14097	SYNPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14098	SYNPO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14099	SYNPO2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Synpo	NCBI	NCBI:11346