Sncb - synuclein, beta Gene

Also Known as betaSYN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104069

Summary

Predicted to enable metal ion binding activity and tubulin binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; dopamine metabolic process; and negative regulation of neuron apoptotic process. Located in synapse. Is expressed in central nervous system; peripheral nervous system; retina; stomach; and testis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Apr 2022]

Sncb Products (2)

mRNA Protein Name
NM_001362407.1 NP_001349336.1 beta-synuclein
NM_033610.3 NP_291088.1 beta-synuclein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
20974939 MGI
acts upstream of or within dopamine metabolic process IGI
IGI: Inferred from genetic interaction
15465911 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
20974939 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
25009269 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
25009269 MGI
Cellular Component GO Annotation Evidence References Source
located in synapse IDA
IDA: Inferred from direct assay
10964942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-synuclein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13486 SNCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sncb NCBI NCBI:6620