2. Gene
  3. Sncb - synuclein, beta Gene

Sncb - synuclein, beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as betaSYN

Gene ID: 104069 | Gene type: protein coding

About Sncb

Summary

Predicted to enable metal ion binding activity and tubulin binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; dopamine metabolic process; and negative regulation of neuron apoptotic process. Located in synapse. Is expressed in central nervous system; peripheral nervous system; retina; stomach; and testis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Apr 2022]

Sncb Products(2)

mRNA Protein Name
NM_001362407.1 NP_001349336.1 beta-synuclein
NM_033610.3 NP_291088.1 beta-synuclein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
20974939 MGI
acts upstream of or within dopamine metabolic process IGI
IGI: Inferred from genetic interaction
15465911 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
20974939 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
25009269 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
25009269 MGI
Cellular Component GO Annotation Evidence Reference Source
located in synapse IDA
IDA: Inferred from direct assay
10964942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-synuclein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13486 SNCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sncb NCBI NCBI:6620