Gas8 - growth arrest specific 8 Gene

Also Known as Gas11

Species: Mus musculus

Gene Type: protein coding

Gene ID: 104346

Summary

Enables microtubule binding activity and small GTPase binding activity. Involved in positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; and regulation of microtubule binding activity. Acts upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Located in Golgi apparatus; ciliary basal body; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Apr 2022]

Gas8 Products (1)

mRNA	Protein	Name
NM_018855.2	NP_061343.2	dynein regulatory complex subunit 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	17366626	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21659505	MGI
enables small GTPase binding	IDA IDA: Inferred from direct assay	18396146	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axoneme assembly	IMP IMP: Inferred from mutant phenotype	27472056	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	27472056	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	27472056	MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	27472056	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	27472056	MGI
involved in flagellated sperm motility	IEP IEP: Inferred from expression pattern	11751847	MGI
involved in positive regulation of protein localization to cilium	IDA IDA: Inferred from direct assay	21659505	MGI
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21659505	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	18396146	MGI
involved in regulation of microtubule binding	IDA IDA: Inferred from direct assay	17366626	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in 9+2 motile cilium	EXP EXP: Inferred from Experiment	29317443	MGI
located in 9+2 motile cilium	IDA IDA: Inferred from direct assay	27472056	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18396146	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	16643277	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21659505	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	17366626	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	11751847	MGI
located in sperm flagellum	IDA IDA: Inferred from direct assay	11751847	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynein regulatory complex subunit 4	GAS-11 GAS-8 beta growth arrest specific protein 11 growth arrest specific 11 growth arrest specific protein 11 growth arrest-specific protein 8

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05287	GAS8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gas8	NCBI	NCBI:2622