Nhlrc1 - NHL repeat containing 1 Gene

Also Known as EPM2B; B230309E09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105193

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including glycogen biosynthetic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of protein modification process. Located in nucleus and perinuclear region of cytoplasm. Used to study Lafora disease. Human ortholog(s) of this gene implicated in Lafora disease. Orthologous to human NHLRC1 (NHL repeat containing E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nhlrc1 Products (1)

mRNA Protein Name
NM_175340.4 NP_780549.1 E3 ubiquitin-protein ligase NHLRC1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17908927 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17908927 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
24914213 MGI
acts upstream of or within glycogen biosynthetic process IGI
IGI: Inferred from genetic interaction
28536304 MGI
involved in glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
20538597 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
23663739 MGI
acts upstream of or within macromolecule metabolic process IMP
IMP: Inferred from mutant phenotype
23663739 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
17908927 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24914213 MGI
acts upstream of protein ubiquitination IDA
IDA: Inferred from direct assay
17908927 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24914213 MGI
acts upstream of or within regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
24914213 MGI
acts upstream of or within regulation of protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
26976331 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24914213 MGI
acts upstream of or within regulation of protein ubiquitination IGI
IGI: Inferred from genetic interaction
26976331 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
19529779 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17908927 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17908927 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NHLRC1

  • NHL repeat-containing protein 1

  • RING-type E3 ubiquitin transferase NHLRC1

  • malin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09286 NHLRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nhlrc1 NCBI NCBI:378884