Akr1c18 - aldo-keto reductase family 1, member C18 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105349

Summary

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. Acts upstream of or within parturition and progesterone catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c18 Products (4)

mRNA Protein Name
NM_001346535.1 NP_001333464.1 aldo-keto reductase family 1 member C18 isoform 2
NM_134066.3 NP_598827.1 aldo-keto reductase family 1 member C18 isoform 1
NM_001346535.1 NP_001333464.1 aldo-keto reductase family 1 member C18 isoform 2
NM_134066.3 NP_598827.1 aldo-keto reductase family 1 member C18 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: Inferred from direct assay
15471942 MGI
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
15471942 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within parturition IMP
IMP: Inferred from mutant phenotype
15471942 MGI
acts upstream of or within progesterone catabolic process IDA
IDA: Inferred from direct assay
15471942 MGI
acts upstream of or within progesterone catabolic process IMP
IMP: Inferred from mutant phenotype
15471942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member C18

  • 20-alpha-HSD

  • 20-alpha-hydroxysteroid dehydrogenase

  • 20alpha-HSD

  • 20alpha-hydroxysteroid dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS23044 Akr1c3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown