HTATIP2 - HIV-1 Tat interactive protein 2 Gene

Also Known as CC3; TIP30; SDR44U1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10553

About HTATIP2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,363,714-20,383,782 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in duodenum (RPKM 33.4), small intestine (RPKM 30.9) and 24 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

HTATIP2 Products (5)

mRNA Protein Name
NM_001098520.2 NP_001091990.1 oxidoreductase HTATIP2 isoform a precursor
NM_001098521.2 NP_001091991.1 oxidoreductase HTATIP2 isoform b
NM_001098522.2 NP_001091992.1 oxidoreductase HTATIP2 isoform b
NM_001098523.2 NP_001091993.1 oxidoreductase HTATIP2 isoform c
NM_006410.5 NP_006401.3 oxidoreductase HTATIP2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15282309 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10698937 GOA
Biological Process GO Annotation Evidence References Source
involved in import into nucleus IDA
IDA: Inferred from direct assay
15282309 GOA
acts upstream of or within positive regulation of programmed cell death IDA
IDA: Inferred from direct assay
10698937 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10698937 GOA
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
10698937 GOA
involved in regulation of angiogenesis IDA
IDA: Inferred from direct assay
11313954 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15282309 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
15282309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTATIP2 Protein Structure

NAD_binding_10

NAD_binding_10: NAD(P)H-binding (22 - 211)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

oxidoreductase HTATIP2

  • 30 kDa HIV-1 TAT-interacting protein

Related Diseases

Diseases Alias
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Gnathodiaphyseal Dysplasia

  • GDD

  • Osteogenesis Imperfecta With Unusual Skeletal Lesions

  • Gnathodiaphyseal Sclerosis

  • Osteogenesis Imperfecta, Levin Type

  • Levin Syndrome 2

  • Dysplasia, Gnathodiaphyseal
Gallbladder Adenocarcinoma

  • Adenocarcinoma Of The Gallbladder

  • Carcinoma Of The Gallbladder
Small Cell Cancer Of The Lung

  • Small Cell Lung Cancer

  • Small Cell Lung Carcinoma

  • Sclc

  • Small-Cell Cancer Of Lung

  • Lung Small Cell Carcinoma

  • Sclc1

  • Sccl

  • Cancer, Lung, Small Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06453 HTATIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HTATIP2 VGNC VGNC:62854
Mus musculus HTATIP2 MGD MGI:1859271
Canis familiaris HTATIP2 VGNC VGNC:41821
Rattus norvegicus HTATIP2 RGD RGD:1309941
Bos taurus HTATIP2 VGNC VGNC:29989
Others HTATIP2 NCBI