ERN2 - endoplasmic reticulum to nucleus signaling 2 Gene

Also Known as IRE1b; IRE2p; hIRE2p; IRE1-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10595

About ERN2

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,690,310-23,713,222 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 1 paralogue. Biased expression in stomach (RPKM 26.7), colon (RPKM 17.0) and 5 other tissues.

Summary

Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be integral component of membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. [provided by Alliance of Genome Resources, Apr 2022]

ERN2 Products (2)

mRNA	Protein	Name
NM_001308220.2	NP_001295149.2	serine/threonine-protein kinase/endoribonuclease IRE2 isoform b precursor
NM_033266.4	NP_150296.4	serine/threonine-protein kinase/endoribonuclease IRE2 isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11175748	GOA
enables endonuclease activity	IDA IDA: Inferred from direct assay	11175748	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11175748	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11175748	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	11175748	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11175748	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11175748	GOA
involved in rRNA catabolic process	IDA IDA: Inferred from direct assay	11175748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERN2 Protein Structure

Pkinase

Ribonuc_2-5A

0
200
400
600
800
974 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase/endoribonuclease IRE2	ER to nucleus signalling 2

Related Diseases

Diseases	Alias
Ileocolitis	Iieocolitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04510	ERN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ERN2	VGNC	VGNC:72283
Rattus norvegicus	ERN2	RGD	RGD:1308743
Felis catus	ERN2	VGNC	VGNC:61953
Canis familiaris	ERN2	VGNC	VGNC:40465
Mus musculus	ERN2	MGD	MGI:1349436
Bos taurus	ERN2	VGNC	VGNC:28593
Others	ERN2	NCBI