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Prickle1 - prickle planar cell polarity protein 1 Gene

Also Known as Pk1; mpk1; Prickle; b2b019Clo; 1110058P22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 106042

Summary

Predicted to enable zinc ion binding activity. Acts upstream of or within aorta development and coronary vasculature development. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study autosomal recessive Robinow syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Prickle1 Products (2)

mRNA	Protein	Name
NM_001033217.5	NP_001028389.1	prickle-like protein 1
NM_001364846.1	NP_001351775.1	prickle-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19788910	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	27378169	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	29450535	MGI
involved in animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in anterior visceral endoderm cell migration	IMP IMP: Inferred from mutant phenotype	19706528	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in basement membrane organization	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in cell migration	IGI IGI: Inferred from genetic interaction	1923957	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26883626	MGI
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in cellular component organization	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	26883626	MGI
involved in cilium organization	IMP IMP: Inferred from mutant phenotype	26883626	MGI
involved in cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	29450535	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	26883626	MGI
involved in cytoskeleton-dependent intracellular transport	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	23420014	MGI
involved in embryonic brain development	IMP IMP: Inferred from mutant phenotype	17868671	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in embryonic nail plate morphogenesis	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27378169	MGI
involved in establishment of bipolar cell polarity involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	19706528	MGI
involved in establishment of cell polarity	IGI IGI: Inferred from genetic interaction	1923957	MGI
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	27378169	MGI
involved in establishment or maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	19706528	MGI
involved in eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	29450535	MGI
involved in face morphogenesis	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in focal adhesion disassembly	IMP IMP: Inferred from mutant phenotype	27378169	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	26883626	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in maintenance of postsynaptic density structure	IDA IDA: Inferred from direct assay	34613779	MGI
involved in maintenance of postsynaptic density structure	IMP IMP: Inferred from mutant phenotype	34613779	MGI
involved in mesenchyme development	IMP IMP: Inferred from mutant phenotype	29450535	MGI
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	19706528	MGI
involved in multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	17868671	MGI
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	28837644	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	23420014	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in polarized secretion of basement membrane proteins in epithelium	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	23913870	MGI
involved in primitive streak formation	IMP IMP: Inferred from mutant phenotype	19706528	MGI
involved in programmed cell death	IMP IMP: Inferred from mutant phenotype	29450535	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	34613779	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	34613779	MGI
involved in renal tubule development	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	21276947	MGI
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	21276947	MGI
involved in tear secretion	IMP IMP: Inferred from mutant phenotype	33144400	MGI
involved in tissue development	IMP IMP: Inferred from mutant phenotype	25190059	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	29450535	MGI
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	33144400	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cell trailing edge	IDA IDA: Inferred from direct assay	27378169	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34613779	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	34613779	MGI
is active in membrane	IMP IMP: Inferred from mutant phenotype	27378169	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22333836	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	34613779	MGI
part of proteasome complex	IDA IDA: Inferred from direct assay	25190059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
prickle-like protein 1	prickle homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11093	PRICKLE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prickle1	NCBI	NCBI:144165