Ildr1 - immunoglobulin-like domain containing receptor 1 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 106347

Summary

Enables high-density lipoprotein particle receptor activity. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and positive regulation of peptide hormone secretion. Located in plasma membrane and tricellular tight junction. Is expressed in olfactory epithelium. Used to study autosomal recessive nonsyndromic deafness 42. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 42. Orthologous to human ILDR1 (immunoglobulin like domain containing receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ildr1 Products (3)

mRNA	Protein	Name
NM_001285788.1	NP_001272717.1	immunoglobulin-like domain-containing receptor 1 isoform 1 precursor
NM_001285791.1	NP_001272720.1	immunoglobulin-like domain-containing receptor 1 isoform 3 precursor
NM_134109.2	NP_598870.1	immunoglobulin-like domain-containing receptor 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables high-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	23863714	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23239027	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in epithelial structure maintenance	IDA IDA: Inferred from direct assay	23239027	MGI
acts upstream of establishment of localization in cell	IDA IDA: Inferred from direct assay	23863714	MGI
acts upstream of peptide hormone secretion	IDA IDA: Inferred from direct assay	23863714	MGI
acts upstream of or within positive regulation of peptide hormone secretion	IDA IDA: Inferred from direct assay	23863714	MGI
involved in protein localization to tricellular tight junction	IMP IMP: Inferred from mutant phenotype	25217574	MGI
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	28785060	MGI
involved in response to fatty acid	IMP IMP: Inferred from mutant phenotype	23863714	MGI
involved in tricellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	25217574	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23863714	MGI
located in tight junction	IDA IDA: Inferred from direct assay	23239027	MGI
located in tricellular tight junction	IDA IDA: Inferred from direct assay	25822906	MGI
located in tricellular tight junction	IMP IMP: Inferred from mutant phenotype	25217574	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
immunoglobulin-like domain-containing receptor 1	angulin-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06783	ILDR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ildr1	NCBI	NCBI:286676