Rapgef1 - Rap guanine nucleotide exchange factor (GEF) 1 Gene

Also Known as C3G; Grf2; 4932418O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107746

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including activation of GTPase activity; negative regulation of signal transduction; and platelet-derived growth factor receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef1 Products (4)

mRNA Protein Name
NM_001039086.1 NP_001034175.1 rap guanine nucleotide exchange factor 1 isoform 2
NM_001039087.1 NP_001034176.1 rap guanine nucleotide exchange factor 1 isoform 1
NM_001362702.1 NP_001349631.1 rap guanine nucleotide exchange factor 1 isoform 4
NM_054050.2 NP_473391.1 rap guanine nucleotide exchange factor 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12671687 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12671687 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
16858399 MGI
acts upstream of or within activation of GTPase activity IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
12466202 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
12466202 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
16858399 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
16858399 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
16858399 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16858399 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12466202 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rap guanine nucleotide exchange factor 1

  • guanine nucleotide releasing factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11660 RAPGEF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rapgef1 NCBI NCBI:2889