Chrnb4 - cholinergic receptor, nicotinic, beta polypeptide 4 Gene

Mus musculus

Also known as Acrb4; Acrb-4

Gene ID: 108015 | Gene type: protein coding

About Chrnb4

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of transmission of nerve impulse. Acts upstream of or within several processes, including behavioral response to nicotine; smooth muscle contraction; and synaptic transmission involved in micturition. Located in cholinergic synapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and thymus. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb4 Products(1)

mRNA	Protein	Name
NM_148944.4	NP_683746.1	neuronal acetylcholine receptor subunit beta-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	23811311	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	23811311	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	15275829	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	15275829	MGI
acts upstream of or within neuronal action potential	IGI IGI: Inferred from genetic interaction	10531434	MGI
involved in positive regulation of transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	12606764	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10771006	MGI
acts upstream of or within response to nicotine	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within smooth muscle contraction	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within synaptic transmission involved in micturition	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within synaptic transmission involved in micturition	IMP IMP: Inferred from mutant phenotype	10771006	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	12079404	MGI
is active in cholinergic synapse	IMP IMP: Inferred from mutant phenotype	23811311	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12079404	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit beta-4

nicotinic acetylcholine receptor beta4 subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02677	CHRNB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrnb4	NCBI	NCBI:1143

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