Chrnb4 - cholinergic receptor, nicotinic, beta polypeptide 4 Gene

Also Known as Acrb4; Acrb-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108015

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of transmission of nerve impulse. Acts upstream of or within several processes, including behavioral response to nicotine; smooth muscle contraction; and synaptic transmission involved in micturition. Located in cholinergic synapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and thymus. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb4 Products (1)

mRNA Protein Name
NM_148944.4 NP_683746.1 neuronal acetylcholine receptor subunit beta-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
23811311 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
23811311 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to nicotine IMP
IMP: Inferred from mutant phenotype
15275829 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
15275829 MGI
acts upstream of or within neuronal action potential IGI
IGI: Inferred from genetic interaction
10531434 MGI
involved in positive regulation of transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
12606764 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
10771006 MGI
acts upstream of or within response to nicotine IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within smooth muscle contraction IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within synaptic transmission involved in micturition IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within synaptic transmission involved in micturition IMP
IMP: Inferred from mutant phenotype
10771006 MGI
Cellular Component GO Annotation Evidence References Source
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
12079404 MGI
is active in cholinergic synapse IMP
IMP: Inferred from mutant phenotype
23811311 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12079404 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit beta-4

  • nicotinic acetylcholine receptor beta4 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02677 CHRNB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrnb4 NCBI NCBI:1143