2. Gene
  3. Prex2 - phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Gene

Prex2 - phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Depdc2; P-Rex2; D430013K02; 6230420N16Rik; C030045D06Rik

Gene ID: 109294 | Gene type: protein coding

About Prex2

Summary

Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase signaling. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Prex2 Products(2)

mRNA Protein Name
NM_001033636.4 NP_001028808.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 2
NM_029525.1 NP_083801.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
18334636 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18334636 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
24367090 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
24367090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

DEP domain containing 2

DEP domain-containing protein 2

ptdIns(3,4,5)-dependent Rac exchanger 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11086 PREX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prex2 NCBI NCBI:80243