2. Gene
  3. Selenos - selenoprotein S Gene

Selenos - selenoprotein S Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as H4; H-4; H47; H-47; Sels; Vimp; Seps1; 1500011E07Rik

Gene ID: 109815 | Gene type: protein coding

About Selenos

Summary

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]

Selenos Products(4)

mRNA Protein Name
NM_001348246.1 NP_001335175.1 selenoprotein S isoform 2
NM_024439.3 NP_077759.3 selenoprotein S isoform 1
NM_001348246.1 NP_001335175.1 selenoprotein S isoform 2
NM_024439.3 NP_077759.3 selenoprotein S isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25009997 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
16227999 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16227999 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenoprotein S

VCP-interacting membrane protein

minor histocompatibility antigen H47

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1000S Selenomethionine-76Se / Unkown
HY-B1000S1 Selenomethionine-77Se / Unkown
HY-RS12642 SELENOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174326 Antibacterial agent 282 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selenos NCBI NCBI:55829