2. Gene
  3. SLC27A2 - solute carrier family 27 member 2 Gene

SLC27A2 - solute carrier family 27 member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226

Gene ID: 11001 | Gene type: protein coding

About SLC27A2

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:50,182,196-50,236,385 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 12 paralogues. Biased expression in liver (RPKM 63.2), kidney (RPKM 62.8) and 5 other tissues.

Summary

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal Enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

SLC27A2 Products(2)

mRNA Protein Name
NM_001159629.2 NP_001153101.1 long-chain fatty acid transport protein 2 isoform 2
NM_003645.4 NP_003636.2 long-chain fatty acid transport protein 2 isoform 1

SLC27A2 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (59 - 487)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (496 - 572)

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  • 620 a.a.
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 2

FATP-2

Related Diseases

Diseases Alias
Adrenoleukodystrophy

X-Linked Adrenoleukodystrophy

ALD

Siemerling-Creutzfeldt Disease

X-Ald

X-Linked Cerebral Adrenoleukodystrophy

Bronze Schilder Disease

Melanodermic Leukodystrophy

Addison Disease And Cerebral Sclerosis

Adrenomyeloneuropathy, Adult

Diffuse Sclerosis

X-Cald

Adrenomyeloneuropathy

Encephalitis Periaxialis Concentrica

Encephalitis Periaxialis, Schilder'S

Sudanophilic Cerebral Sclerosis

Ald Childhood Cerebral Form

Adrenoleukodystrophy X-Linked Cerebral Form

Adrenoleukodystrophy Childhood Cerebral Form

Childhood Cerebral Ald

Schilder Disease

X-Linked Ald

Adrenoleukodystrophy, X-Linked

Amn

Diffuse Cerebral Sclerosis Of Schilder

Systemic Scleroderma

Balo'S Concentric Sclerosis

Ald - [Adrenoleukodystrophy]

Addison-Schilder
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13145 SLC27A2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC27A2 VGNC VGNC:46330
Felis catus SLC27A2 VGNC VGNC:65289
Bos taurus SLC27A2 VGNC VGNC:34786
Mus musculus SLC27A2 MGD MGI:1347099
Macaca mulatta SLC27A2 VGNC VGNC:77439
Rattus norvegicus SLC27A2 RGD RGD:71103