Adgrv1 - adhesion G protein-coupled receptor V1 Gene

Mus musculus

Also known as Mgr1; Gpr98; Mass1; VLGR1; Frings

Gene ID: 110789 | Gene type: protein coding

About Adgrv1

Summary

Enables several functions, including G-protein alpha-subunit binding activity; Adenylate Cyclase Inhibitor activity; and Myosin binding activity. Involved in several processes, including negative regulation of Adenylate Cyclase activity; positive regulation of bone mineralization; and positive regulation of protein kinase C signaling. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; and positive regulation of protein kinase A signaling. Located in several cellular components, including periciliary membrane compartment; photoreceptor connecting cilium; and stereocilia ankle link. Part of USH2 complex and stereocilia ankle link complex. Is active in stereocilium. Is expressed in several structures, including brain; eye; neural ectoderm; reproductive system; and spinal cord. Used to study Usher syndrome type 2C. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1). [provided by Alliance of Genome Resources, Apr 2022]

Adgrv1 Products(1)

mRNA	Protein	Name
NM_054053.4	NP_473394.3	adhesion G-protein coupled receptor V1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	24962568	MGI
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	24962568	MGI
enables adenylate cyclase inhibitor activity	IDA IDA: Inferred from direct assay	24962568	MGI
enables myosin binding	IPI IPI: Inferred from physical interaction	17567809	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20502675	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	24191038	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	24191038	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16775142	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	24334608	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	24334608	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	16775142	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	17567809	MGI
involved in negative regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	24962568	MGI
acts upstream of or within nervous system process	IMP IMP: Inferred from mutant phenotype	11545713	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	22419726	MGI
acts upstream of or within positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	24191038	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	24191038	MGI
involved in self proteolysis	IDA IDA: Inferred from direct assay	24962568	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15820310	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	16775142	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of USH2 complex	IDA IDA: Inferred from direct assay	20502675	MGI
part of USH2 complex	IPI IPI: Inferred from physical interaction	25406310	MGI
located in periciliary membrane compartment	IDA IDA: Inferred from direct assay	17906286	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21212183	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	17906286	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16775142	MGI
located in stereocilia ankle link	IDA IDA: Inferred from direct assay	16775142	MGI
part of stereocilia ankle link complex	IDA IDA: Inferred from direct assay	17567809	MGI
is active in stereocilium	EXP EXP: Inferred from Experiment	26754646	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adhesion G-protein coupled receptor V1

G-protein coupled receptor 98	monogenic audiogenic seizure susceptibility protein 1
monogenic, audiogenic seizure susceptibility 1	neurepin
protein rueda	very large G protein-coupled receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00365	ADGRV1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adgrv1	NCBI	NCBI:84059

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