Atp6v1b1 - ATPase, H+ transporting, lysosomal V1 subunit B1 Gene

Mus musculus

Also known as Vpp3; Vpp-3; Atp6b1; D630003L15; D630030L16Rik; D630039P21Rik

Gene ID: 110935 | Gene type: protein coding

About Atp6v1b1

Summary

Enables proton transmembrane transporter activity. Involved in proton transmembrane transport. Acts upstream of or within several processes, including inorganic ion homeostasis; renal sodium ion transport; and renal water homeostasis. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and microvillus. Is expressed in several structures, including alimentary system; limb; metanephros; nervous system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness and enlarged vestibular aqueduct. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v1b1 Products(1)

mRNA	Protein	Name
NM_134157.3	NP_598918.1	V-type proton ATPase subunit B, kidney isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proton transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16174750	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ATP metabolic process	IMP IMP: Inferred from mutant phenotype	24051376	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	23028982	MGI
acts upstream of or within chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	24051376	MGI
NOT involved in inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	12782355	MGI
acts upstream of or within olfactory behavior	IMP IMP: Inferred from mutant phenotype	23028982	MGI
acts upstream of or within potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	24051376	MGI
acts upstream of or within prostaglandin metabolic process	IMP IMP: Inferred from mutant phenotype	24051376	MGI
involved in proton transmembrane transport	IMP IMP: Inferred from mutant phenotype	17898041	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23269648	MGI
acts upstream of or within regulation of pH	IMP IMP: Inferred from mutant phenotype	16174750	MGI
involved in regulation of pH	IMP IMP: Inferred from mutant phenotype	17898041	MGI
acts upstream of or within renal sodium excretion	IMP IMP: Inferred from mutant phenotype	24051376	MGI
acts upstream of or within renal sodium ion transport	IMP IMP: Inferred from mutant phenotype	24051376	MGI
acts upstream of or within renal water homeostasis	IMP IMP: Inferred from mutant phenotype	24051376	MGI
NOT involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	12782355	MGI
involved in synaptic vesicle lumen acidification	EXP EXP: Inferred from Experiment	28793259	MGI
involved in synaptic vesicle lumen acidification	IDA IDA: Inferred from direct assay	28793259	MGI
involved in synaptic vesicle lumen acidification	IMP IMP: Inferred from mutant phenotype	28793259	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16077082	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	14585495	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17392376	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17898041	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	18667600	MGI
located in membrane	IDA IDA: Inferred from direct assay	14585495	MGI
located in microvillus	IDA IDA: Inferred from direct assay	17392376	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

V-type proton ATPase subunit B, kidney isoform

ATPase, H+ transporting, V1 subunit B	ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B	V-ATPase subunit B 1
endomembrane proton pump 58 kDa subunit	vacuolar proton pum

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01224	ATP6V1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp6v1b1	NCBI	NCBI:525

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