Atp6v1b1 - ATPase, H+ transporting, lysosomal V1 subunit B1 Gene

Also Known as Vpp3; Vpp-3; Atp6b1; D630003L15; D630030L16Rik; D630039P21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110935

Summary

Enables proton transmembrane transporter activity. Involved in proton transmembrane transport. Acts upstream of or within several processes, including inorganic ion homeostasis; renal sodium ion transport; and renal water homeostasis. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and microvillus. Is expressed in several structures, including alimentary system; limb; metanephros; nervous system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness and enlarged vestibular aqueduct. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v1b1 Products (1)

mRNA Protein Name
NM_134157.3 NP_598918.1 V-type proton ATPase subunit B, kidney isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proton transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16174750 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ATP metabolic process IMP
IMP: Inferred from mutant phenotype
24051376 MGI
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
23028982 MGI
acts upstream of or within chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
24051376 MGI
NOT involved in inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
12782355 MGI
acts upstream of or within olfactory behavior IMP
IMP: Inferred from mutant phenotype
23028982 MGI
acts upstream of or within potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
24051376 MGI
acts upstream of or within prostaglandin metabolic process IMP
IMP: Inferred from mutant phenotype
24051376 MGI
involved in proton transmembrane transport IMP
IMP: Inferred from mutant phenotype
17898041 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23269648 MGI
acts upstream of or within regulation of pH IMP
IMP: Inferred from mutant phenotype
16174750 MGI
involved in regulation of pH IMP
IMP: Inferred from mutant phenotype
17898041 MGI
acts upstream of or within renal sodium excretion IMP
IMP: Inferred from mutant phenotype
24051376 MGI
acts upstream of or within renal sodium ion transport IMP
IMP: Inferred from mutant phenotype
24051376 MGI
acts upstream of or within renal water homeostasis IMP
IMP: Inferred from mutant phenotype
24051376 MGI
NOT involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
12782355 MGI
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16077082 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
14585495 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17392376 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17898041 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
18667600 MGI
located in membrane IDA
IDA: Inferred from direct assay
14585495 MGI
located in microvillus IDA
IDA: Inferred from direct assay
17392376 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase subunit B, kidney isoform

  • ATPase, H+ transporting, V1 subunit B

  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa

  • ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B

  • V-ATPase subunit B 1

  • endomembrane proton pump 58 kDa subunit

  • vacuolar proton pum

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01224 ATP6V1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6v1b1 NCBI NCBI:525