FAM107A - family with sequence similarity 107 member A Gene

Also Known as DRR1; TU3A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11170

About FAM107A

Cytogenetic location: 3p14.3-p14.2 Genomic coordinates (GRCh38): 3:58,564,117-58,627,610 (from NCBI)

This gene has 8 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in brain (RPKM 151.8), lung (RPKM 18.6) and 7 other tissues.

Summary

Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of Cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

FAM107A Products (4)

mRNA	Protein	Name
NM_001076778.3	NP_001070246.1	actin-associated protein FAM107A isoform a
NM_001282713.2	NP_001269642.1	actin-associated protein FAM107A isoform b
NM_001282714.2	NP_001269643.1	actin-associated protein FAM107A isoform c
NM_007177.4	NP_009108.1	actin-associated protein FAM107A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20543869	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	28604741	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	20543869	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20543869	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	28604741	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20543869	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	10564580	GOA
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20543869	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	28604741	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	28604741	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28604741	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	20543869	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10564580	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	20543869	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	20543869	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM107A Protein Structure

DUF1151

0
100
144 a.a.

Protein Preferred Names	Protein Names
actin-associated protein FAM107A	down-regulated in renal cell carcinoma 1

Related Diseases

Diseases	Alias
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Van Den Ende-Gupta Syndrome	VDEGS Blepharophimosis, Arachnodactyly, And Congenital Contractures Marden-Walker-Like Syndrome Marden-Walker-Like Syndrome Without Psychomotor Retardation Marden Walker Like Syndrome Marden-Walker-Like Syndrome Without Psychmotor Retardation Van Den Ende Gupta Syndrome Marden Walker Like Syndrome Without Psychomotor Retardation Blepharophimosis Arachnodactyly And Congenital Contractures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS04676	FAM107A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM107A	RGD	RGD:1306327
Bos taurus	FAM107A	VGNC	VGNC:28713
Macaca mulatta	FAM107A	VGNC	VGNC:72416
Canis familiaris	FAM107A	VGNC	VGNC:40575
Mus musculus	FAM107A	MGD	MGI:3041256
Felis catus	FAM107A	VGNC	VGNC:62046
Others	FAM107A	NCBI