FAM107A - family with sequence similarity 107 member A Gene

Homo sapiens

Also known as DRR1; TU3A

Gene ID: 11170 | Gene type: protein coding

About FAM107A

Cytogenetic location: 3p14.3-p14.2 Genomic coordinates (GRCh38): 3:58,564,117-58,627,610 (from NCBI)

This gene has 8 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in brain (RPKM 151.8), lung (RPKM 18.6) and 7 other tissues.

Summary

Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of Cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

FAM107A Products(4)

mRNA	Protein	Name
NM_001076778.3	NP_001070246.1	actin-associated protein FAM107A isoform a
NM_001282713.2	NP_001269642.1	actin-associated protein FAM107A isoform b
NM_001282714.2	NP_001269643.1	actin-associated protein FAM107A isoform c
NM_007177.4	NP_009108.1	actin-associated protein FAM107A isoform a

FAM107A Protein Structure

DUF1151

0
100
144 a.a.

Protein Preferred Names

Protein Names

actin-associated protein FAM107A

down-regulated in renal cell carcinoma 1

Related Diseases

Diseases

Alias

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04676	FAM107A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM107A	RGD	RGD:1306327
Bos taurus	FAM107A	VGNC	VGNC:28713
Macaca mulatta	FAM107A	VGNC	VGNC:72416
Canis familiaris	FAM107A	VGNC	VGNC:40575
Mus musculus	FAM107A	MGD	MGI:3041256
Felis catus	FAM107A	VGNC	VGNC:62046

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