CELF3 - CUGBP Elav-like family member 3 Gene

Also Known as CAGH4; ERDA4; ETR-1; TNRC4; BRUNOL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11189

About CELF3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,700,058-151,716,803 (from NCBI)

This gene has 7 transcripts (splice variants), 278 orthologues and 6 paralogues. Biased expression in brain (RPKM 11.4), adrenal (RPKM 3.2) and 4 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

CELF3 Products (5)

mRNA	Protein	Name
NM_001172648.4	NP_001166119.1	CUGBP Elav-like family member 3 isoform 2
NM_001172649.4	NP_001166120.1	CUGBP Elav-like family member 3 isoform 3
NM_001291106.2	NP_001278035.1	CUGBP Elav-like family member 3 isoform 4
NM_001291107.2	NP_001278036.1	CUGBP Elav-like family member 3 isoform 5
NM_007185.7	NP_009116.3	CUGBP Elav-like family member 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	17725984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	17725984	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15009664	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	11158314	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17725984	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17725984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELF3 Protein Structure

RRM_1

0
100
200
300
400
465 a.a.

Protein Preferred Names	Protein Names
CUGBP Elav-like family member 3	CAG repeat domain

Related Diseases

Diseases	Alias
Specific Language Impairment	Language Impairment, Specific
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Palmoplantar Keratoderma, Bothnian Type	PPKB Diffuse Palmoplantar Keratoderma, Bothnian Type Bothnian Type Palmoplantar Keratoderma Keratoderma, Palmoplantar, Bothnian Type Palmoplantar Keratoderma, Nonepidermolytic
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Speech Disorder	Speech Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02461	CELF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CELF3	VGNC	VGNC:60746
Canis familiaris	CELF3	VGNC	VGNC:39095
Bos taurus	CELF3	VGNC	VGNC:27168
Macaca mulatta	CELF3	VGNC	VGNC:70936
Mus musculus	CELF3	MGD	MGI:1926034
Rattus norvegicus	CELF3	RGD	RGD:1563168
Others	CELF3	NCBI