KLF8 - KLF transcription factor 8 Gene

Also Known as BKLF3; ZNF741

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11279

About KLF8

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,908,123-56,291,531 (from NCBI)

This gene has 6 transcripts (splice variants), 193 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues.

Summary

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KLF8 Products (7)

mRNA Protein Name
NM_001159296.2 NP_001152768.1 Krueppel-like factor 8 isoform 2
NM_001324099.1 NP_001311028.1 Krueppel-like factor 8 isoform 3
NM_001324100.1 NP_001311029.1 Krueppel-like factor 8 isoform 4
NM_001324102.1 NP_001311031.1 Krueppel-like factor 8 isoform 1
NM_001324104.1 NP_001311033.1 Krueppel-like factor 8 isoform 5
NM_001324105.1 NP_001311034.1 Krueppel-like factor 8 isoform 6
NM_007250.5 NP_009181.2 Krueppel-like factor 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10756197 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
10756197 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10756197 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10756197 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF8 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (290 - 311)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (321 - 345)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

Krueppel-like factor 8

  • Kruppel like factor 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07345 KLF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLF8 MGD MGI:2442430
Bos taurus KLF8 VGNC VGNC:52791
Felis catus KLF8 VGNC VGNC:67956
Rattus norvegicus KLF8 RGD RGD:1565831
Macaca mulatta KLF8 VGNC VGNC:74183
Canis familiaris KLF8 VGNC VGNC:42438
Others KLF8 NCBI