EXOSC6 - exosome component 6 Gene

Also Known as p11; EAP4; MTR3; Mtr3p; hMtr3p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 118460

About EXOSC6

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,246,778-70,251,940 (from NCBI)

This gene has 1 transcript (splice variant), 155 orthologues and 2 paralogues.

Summary

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]

EXOSC6 Products (1)

mRNA	Protein	Name
NM_058219.3	NP_478126.1	exosome complex component MTR3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables RNA exonuclease activity	IDA IDA: Inferred from direct assay	17174896	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA deamination	IDA IDA: Inferred from direct assay	21255825	GOA
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	17174896	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	17174896	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	20531386	GOA
part of exosome (RNase complex)	IDA IDA: Inferred from direct assay	20531389	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20531386	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOSC6 Protein Structure

RNase_PH

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
exosome complex component MTR3	Mtr3 (mRNA transport regulator 3)-homolog

Related Diseases

Diseases	Alias
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1b	Pontocerebellar Hypoplasia Type 1b PCH1B Pontocerebellar Hypoplasia 1b Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1c	PCH1C Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia Pontocerebellar Hypoplasia Type 1c Pontocerebellar Hypoplasia 1c Doid:0112334 Hypoplasia, Pontocerebellar, Type 1c
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Trichohepatoenteric Syndrome 2	THES2
Plantar Wart	Verruca Plantaris Verrucae On Sole Of Foot Mosaic Plantar Warts
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04602	EXOSC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EXOSC6	RGD	RGD:1309832
Bos taurus	EXOSC6	VGNC	VGNC:106728
Mus musculus	EXOSC6	MGD	MGI:1919794