ADH1A - alcohol dehydrogenase 1A (class I), alpha polypeptide Gene

Also Known as ADH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 124

About ADH1A

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,276,369-99,290,985 (from NCBI)

This gene has 3 transcripts (splice variants), 372 orthologues and 17 paralogues. Biased expression in liver (RPKM 735.3) and fat (RPKM 36.3).

Summary

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

ADH1A Products (1)

mRNA	Protein	Name
NM_000667.4	NP_000658.1	alcohol dehydrogenase 1A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	9982	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16153155	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in alcohol metabolic process	IDA IDA: Inferred from direct assay	2738060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH1A Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
375 a.a.

Protein Preferred Names	Protein Names
alcohol dehydrogenase 1A	ADH, alpha subunit

ADH1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82203	Alcohol Dehydrogenase Antibody (YA1948)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Substance Dependence
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Kenny-Caffey Syndrome, Type 1	KCS1 Kenny-Caffey Syndrome Type 1 Autosomal Recessive Kenny-Caffey Syndrome Kcs Kenny-Caffey Syndrome, Autosomal Recessive Kenny-Caffey Syndrome 1 Kenny-Caffey Syndrome Autosomal Recessive Kenny-Caffey Syndrome-1
Familial Isolated Hypoparathyroidism	Fih
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00366	ADH1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27366	Adh1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADH1A	MGD	MGI:87921