PLK5 - polo like kinase 5 (inactive) Gene

Also Known as PLK-5; PLK5P; SgK384ps

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126520

About PLK5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,508,023-1,536,046 (from NCBI)

This gene has 10 transcripts (splice variants), 98 orthologues and 4 paralogues. Biased expression in testis (RPKM 2.5), endometrium (RPKM 1.6) and 3 other tissues.

Summary

Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLK5 Products (3)

mRNA Protein Name
NM_001011716.1
NR_026557.1
NM_001243079.2 NP_001230008.1 inactive serine/threonine-protein kinase PLK5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
21245385 GOA
involved in defense response to tumor cell IDA
IDA: Inferred from direct assay
21245385 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
21245385 GOA
involved in regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21245385 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21245385 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21245385 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive serine/threonine-protein kinase PLK5

  • polo-like kinase 5, pseudogene

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10723 PLK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10724 Plk5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10725 Plk5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLK5 RGD RGD:1305038
Mus musculus PLK5 MGD MGI:3026984