PUSL1 - pseudouridine synthase like 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126789

About PUSL1

This gene has 5 transcripts (splice variants), 182 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 3.5), testis (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PUSL1 Products (2)

mRNA Protein Name
NM_001346116.2 NP_001333045.1 tRNA pseudouridine synthase-like 1 isoform 1
NM_153339.3 NP_699170.1 tRNA pseudouridine synthase-like 1 isoform 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
28082677 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PUSL1 Protein Structure

PseudoU_synth_1

PseudoU_synth_1: tRNA pseudouridine synthase (18 - 123)

PseudoU_synth_1

PseudoU_synth_1: tRNA pseudouridine synthase (168 - 284)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

tRNA pseudouridine synthase-like 1

  • pseudouridylate synthase like 1

Related Diseases

Diseases Alias
Myopathy, Lactic Acidosis, And Sideroblastic Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11471 PUSL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PUSL1 VGNC VGNC:81515
Bos taurus PUSL1 VGNC VGNC:33578
Mus musculus PUSL1 MGD MGI:3047787
Canis familiaris PUSL1 VGNC VGNC:49842
Felis catus PUSL1 VGNC VGNC:80332
Rattus norvegicus PUSL1 RGD RGD:1559560
Others PUSL1 NCBI