2. Gene
  3. PPM1M - protein phosphatase, Mg2+/Mn2+ dependent 1M Gene

PPM1M - protein phosphatase, Mg2+/Mn2+ dependent 1M Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP2CE; PP2Ceta; PP2C-eta

Gene ID: 132160 | Gene type: protein coding

About PPM1M

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,245,759-52,250,599 (from NCBI)

This gene has 9 transcripts (splice variants), 501 orthologues and 16 paralogues. Ubiquitous expression in lymph node (RPKM 16.5), spleen (RPKM 14.7) and 25 other tissues.

Summary

Predicted to enable manganese ion binding activity and phosphoprotein Phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PPM1M Products(2)

mRNA Protein Name
NM_001122870.3 NP_001116342.1 protein phosphatase 1M isoform b
NM_144641.4 NP_653242.3 protein phosphatase 1M isoform a

PPM1M Protein Structure

PP2C

PP2C: Protein phosphatase 2C (24 - 104)

PP2C

PP2C: Protein phosphatase 2C (147 - 246)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1M

protein phosphatase 1M (PP2C domain containing)

Related Diseases

Diseases Alias
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Autosomal Dominant Keratitis

Hereditary Keratitis

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KERH
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Acrodysplasia

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Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10970 PPM1M Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPM1M MGD MGI:1915155
Canis familiaris PPM1M VGNC VGNC:44872
Macaca mulatta PPM1M VGNC VGNC:84145
Felis catus PPM1M VGNC VGNC:64315
Bos taurus PPM1M VGNC VGNC:33217
Rattus norvegicus PPM1M RGD RGD:1584266