SGCZ - sarcoglycan zeta Gene

Homo sapiens

Also known as ZSG1

Gene ID: 137868 | Gene type: protein coding

About SGCZ

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:14,084,845-15,238,431 (from NCBI)

This gene has 2 transcripts (splice variants), 247 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner Cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]

SGCZ Products(4)

mRNA	Protein	Name
NM_001322879.2	NP_001309808.1	zeta-sarcoglycan isoform 2
NM_001322880.2	NP_001309809.1	zeta-sarcoglycan isoform 3
NM_001322881.2	NP_001309810.1	zeta-sarcoglycan isoform 4
NM_139167.4	NP_631906.2	zeta-sarcoglycan isoform 1

SGCZ Protein Structure

Sarcoglycan_1

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

zeta-sarcoglycan

zeta-SG

Related Diseases

Diseases

Alias

Hallucinogen Abuse

Dystonia 11, Myoclonic

Myoclonic Dystonia	Myoclonus-Dystonia Syndrome
DYT11	Myoclonic Dystonia 11
Alcohol-Responsive Dystonia	Myoclonus, Hereditary Essential
Dystonia-11, Myoclonic	Myoclonus-Dystonia
Dystonia 11	Hereditary Essential Myoclonus
Dystonia, Alcohol-Responsive	Dyt-Sgce
Dystonia, Alcohol Responsive	Dystonia-11
Dystonia, Myoclonic	Dystonia, Myoclonic, Type 11

Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma	Embryonal Carcinoma Of Testis
Embryonal Carcinoma Of The Testis

Otopalatodigital Syndrome, Type Ii

Otopalatodigital Syndrome Type 2	Faciopalatoosseous Syndrome
OPD2	Opd Ii Syndrome
Opd Syndrome 2	Cranioorodigital Syndrome
Fpo	Oto-Palato-Digital Syndrome, Type Ii
Andre Syndrome	Oto-Palato-Digital Syndrome Type 2
Otopalatodigital Syndrome Type Ii	Cranio-Oro-Digital Syndrome
Opd 2 Syndrome	Opd Syndrome, Type 2
Taybi Syndrome	Otopalatodigital Syndrome 2
Oto-Palato-Digital Syndrome, Type 2	Oto-Palato-Digital Syndrome Type 1

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2

Lgmd2b	Muscular Dystrophy, Limb-Girdle, Type 2b
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e	Beta-Sarcoglycanopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2y	Muscular Dystrophy, Limb-Girdle, Type 3
Lgmd3	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2s
LGMDR2	Muscular Dystrophy, Limb-Girdle, Type 2s
Limb-Girdle Muscular Dystrophy Type 2b	Lgmd2e
Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency	Muscular Dystrophy, Limb-Girdle, Type 2e
Lgmd2s	Autosomal Recessive Muscular Dystrophy Due To Lap1b Deficiency
Autosomal Recessive Muscular Dystrophy Due To Torsin-1a-Interacting Protein 1 Deficiency	Lgmd2y
Muscular Dystrophy With Progressive Weakness, Distal Contractures And Rigid Spine	Muscular Dystrophy, Limb-Girdle, Type 2y
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b
Dysferlin-Related Lgmd R2	Lgmd Due To Dysferlin Deficiency
Lgmd Type 2b	Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency
Limb-Girdle Muscular Dystrophy 2b	Limb-Girdle Muscular Dystrophy, Type 2b
Dystrophy, Muscular, Limb-Girdle, Autosomal Recessive, Type 2	Dystrophy, Muscular, Limb-Girdle, Type 2b
Limb-Girdle Muscular Dystrophy, Type 2e

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12795	SGCZ Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SGCZ	RGD	RGD:1307788
Canis familiaris	SGCZ	VGNC	VGNC:49686
Macaca mulatta	SGCZ	VGNC	VGNC:77230
Felis catus	SGCZ	VGNC	VGNC:107463
Mus musculus	SGCZ	MGD	MGI:2388820