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ASB11 - ankyrin repeat and SOCS box containing 11 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140456

About ASB11

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,281,697-15,315,640 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 2 paralogues. Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ASB11 Products (3)

mRNA	Protein	Name
NM_001012428.2	NP_001012428.1	ankyrin repeat and SOCS box protein 11 isoform b
NM_001201583.2	NP_001188512.1	ankyrin repeat and SOCS box protein 11 isoform c
NM_080873.3	NP_543149.1	ankyrin repeat and SOCS box protein 11 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	24337577	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	31387940	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	38574733	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	24337577	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	31387940	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24337577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB11 Protein Structure

Ank_2

Ank

Ank_2

SOCS_box

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and SOCS box protein 11	ASB-11

Related Diseases

Diseases	Alias
Lacrimal Duct Obstruction	Blocked Lacrimal Canaliculus Obstruction Of Lacrimal Canaliculus Obstruction Of Lacrimal Ducts
Myiasis	Infestation By Fly Larvae Infestation By Maggots Maggot Infestation Infestation By Larvae Of Flies Infestation By Dermatobia Infestation By Estrus Ovis Infestation By Oestrus Ovis Oestriasis Oestrosis
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01060	ASB11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASB11	VGNC	VGNC:26188
Mus musculus	ASB11	MGD	MGI:1916104
Rattus norvegicus	ASB11	RGD	RGD:1566298
Felis catus	ASB11	VGNC	VGNC:59956
Canis familiaris	ASB11	VGNC	VGNC:38156
Others	ASB11	NCBI