RIMS4 - regulating synaptic membrane exocytosis 4 Gene

Also Known as RIM4; RIM 4; RIM-4; C20orf190; RIM4gamma; RIM4-gamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140730

About RIMS4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,751,808-44,810,546 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 4 paralogues. Biased expression in brain (RPKM 10.7), testis (RPKM 10.4) and 8 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in regulation of membrane potential; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

RIMS4 Products (2)

mRNA Protein Name
NM_001205317.2 NP_001192246.1 regulating synaptic membrane exocytosis protein 4 isoform 1
NM_182970.4 NP_892015.1 regulating synaptic membrane exocytosis protein 4 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIMS4 Protein Structure

C2

C2: C2 domain (130 - 216)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

regulating synaptic membrane exocytosis protein 4

  • RIM4 gamma

Related Diseases

Diseases Alias
Partial Trisomy Distal 4q

  • Distal Trisomy 4q

  • Chromosome 4, Partial Trisomy 4q

  • Distal 4q Trisomy

  • Dup Syndrome, Partial

  • Duplication 4q Syndrome, Partial

  • Partial Trisomy 4q Syndrome

  • Distal Duplication 4q

  • Telomeric Duplication 4q

  • Trisomy 4qter
Heimler Syndrome 2

  • HMLR2

  • Peroxisome Biogenesis Disorder 4c

  • Pbd4c

  • Peroxisomal Biogenesis Disorder 4c

  • Heimler Syndrome, Type 2
Cone-Rod Dystrophy 7

  • CORD7

  • Dystrophy, Cone-Rod, Type 7

  • Retinitis Pigmentosa 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11981 RIMS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RIMS4 MGD MGI:2674366
Canis familiaris RIMS4 VGNC VGNC:45585
Rattus norvegicus RIMS4 RGD RGD:628695
Bos taurus RIMS4 VGNC VGNC:33974
Macaca mulatta RIMS4 VGNC VGNC:76743