DNHD1 - dynein heavy chain domain 1 Gene

Homo sapiens

Also known as DHCD1; CCDC35; DNHD1L; SPGF65; C11orf47

Gene ID: 144132 | Gene type: protein coding

About DNHD1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,497,280-6,572,020 (from NCBI)

This gene has 18 transcripts (splice variants), 177 orthologues, 15 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 7.9), spleen (RPKM 1.7) and 18 other tissues.

Summary

Predicted to enable dynein intermediate chain binding activity; dynein LIGHT intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

DNHD1 Products(2)

mRNA	Protein	Name
NM_144666.3	NP_653267.2	dynein heavy chain domain-containing protein 1 isoform 1
NM_173589.4	NP_775860.3	dynein heavy chain domain-containing protein 1 isoform 2

DNHD1 Protein Structure

DHC_N2

AAA_6

AAA_7

Dynein_heavy

0
800
1600
2400
3200
4000
4753 a.a.

Protein Preferred Names

Protein Names

dynein heavy chain domain-containing protein 1

DNHD1 variant protein

Related Diseases

Diseases

Alias

Spermatogenic Failure 65

SPGF65

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Pancreatic Squamous Cell Carcinoma

Spondylocostal Dysostosis 4, Autosomal Recessive

SCDO4	Spondylocostal Dysostosis 4
Autosomal Recessive Spondylocostal Dysostosis 4	Doid:0112364
Dysostosis, Spondylocostal, Autosomal Recessive, Type 4

Immunoglobulin A Deficiency 1

Immunoglobulin A Deficiency	Selective Iga Deficiency Disease
Selective Immunoglobulin A Deficiency	IGAD1
Immunoglobulin A, Selective Deficiency Of	Iga, Selective Deficiency Of
Gamma-A-Globulin, Selective Deficiency Of	Selective Iga Immunodeficiency
Selective Iga Deficiency	Iga Deficiency Selective

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03901	DNHD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNHD1	VGNC	VGNC:107445
Felis catus	DNHD1	VGNC	VGNC:82389
Bos taurus	DNHD1	VGNC	VGNC:28140
Mus musculus	DNHD1	MGD	MGI:1924755
Canis familiaris	DNHD1	VGNC	VGNC:40030
Rattus norvegicus	DNHD1	RGD	RGD:1584052

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