OTOA - otoancorin Gene

Also Known as CT108; DFNB22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 146183

About OTOA

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:21,663,968-21,760,729 (from NCBI)

This gene has 9 transcripts (splice variants), 134 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 1.9), spleen (RPKM 0.7) and 4 other tissues.

Summary

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

OTOA Products (3)

mRNA	Protein	Name
NM_001161683.2	NP_001155155.1	otoancorin isoform 3
NM_144672.4	NP_653273.3	otoancorin isoform 1 precursor
NM_170664.3	NP_733764.1	otoancorin isoform 2

Protein Preferred Names	Protein Names
otoancorin	cancer/testis antigen 108

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 22	DFNB22 Autosomal Recessive Nonsyndromic Deafness 22 Autosomal Recessive Deafness 22 Deafness, Autosomal Recessive, 22 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Deafness, Autosomal Recessive
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Rare Genetic Deafness	Rare Genetic Hearing Loss
Deafness, Autosomal Recessive 7	DFNB7 Dfnb11 Deafness, Autosomal Recessive 11 Autosomal Recessive Nonsyndromic Deafness 7 Autosomal Recessive Deafness 7 Deafness, Autosomal Recessive, 7 Deafness Neurosensory Autosomal Recessive 11 Deafness Neurosensory Autosomal Recessive 7 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 7 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 7 Deafness, Autosomal Recessive, Type 7
Deafness, Autosomal Dominant 4a	Deafness, Autosomal Dominant 4 DFNA4A Dfna4 Autosomal Dominant Nonsyndromic Deafness 4a Autosomal Dominant Deafness 4a Deafness, Autosomal Dominant, 4a Deafness Autosomal Dominant 4 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 4 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 4 Deafness, Autosomal Dominant, Type 4a
Complement Component 2 Deficiency	C2D C2 Deficiency Complement 2 Deficiency Complement Component-2
Deafness, Autosomal Recessive 16	DFNB16 Autosomal Recessive Nonsyndromic Deafness 16 Autosomal Recessive Deafness 16 Deafness, Autosomal Recessive, 16 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 16 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 16 Deafness, Autosomal Recessive, Type 16
Deafness, Autosomal Recessive 83	DFNB83 Autosomal Recessive Nonsyndromic Deafness 83 Autosomal Recessive Deafness 83
Chromosome 16p12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb	Chromosome 16p12.2-P11.2 Deletion Syndrome 16p11.2p12.2 Microdeletion Syndrome 16p11.2-P12.2 Microdeletion Syndrome Del(16)(P11.2p12.2) Monosomy 16p11.2p12.2 Chromosome Deletion Syndrome 16p12.2-P11.2
Deafness, Autosomal Recessive 85	DFNB85 Autosomal Recessive Nonsyndromic Deafness 85 Autosomal Recessive Deafness 85
Deafness, Autosomal Dominant 40	DFNA40 Autosomal Dominant Nonsyndromic Deafness 40 Autosomal Dominant Deafness 40 Deafness, Autosomal Dominant, 40 Deafness, Autosomal Dominant, Type 40
Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct	Enlarged Vestibular Aqueduct DFNB4 Neurosensory Nonsyndromic Recessive Deafness 4 Enlarged Vestibular Aqueduct Syndrome Nsrd4 Autosomal Recessive Nonsyndromic Deafness 4 Dilated Vestibular Aqueduct Dva Enlarged Vestibular Aqueduct, Digenic Autosomal Recessive Deafness 4 With Enlarged Vestibular Aqueduct Large Vestibular Aqueduct Syndrome Deafness, Autosomal Recessive, 4 Deafness Neurosensory Autosomal Recessive 4 Eva Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 4 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 4 Deafness, Autosomal Recessive, Type 4 , With Enlarged Vestibular Aqueduct
Deafness, Autosomal Dominant 20	DFNA20 Dfna26 Deafness, Autosomal Dominant 20/26 Autosomal Dominant Nonsyndromic Deafness 20 Autosomal Dominant Deafness 20 Deafness, Autosomal Dominant, 20 Deafness Autosomal Dominant 26 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 20 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 20 Deafness, Autosomal Dominant, Type 20/26
Deafness, Autosomal Recessive 89	DFNB89 Autosomal Recessive Nonsyndromic Deafness 89 Autosomal Recessive Deafness 89 Deafness, Autosomal Recessive, 89 Deafness, Autosomal Recessive, Type 89
Deafness, Autosomal Recessive 35	DFNB35 Autosomal Recessive Nonsyndromic Deafness 35 Autosomal Recessive Deafness 35 Deafness, Autosomal Recessive, 35 Deafness, Autosomal Recessive, Type 35
Deafness, Autosomal Recessive 91	DFNB91 Autosomal Recessive Nonsyndromic Deafness 91 Autosomal Recessive Deafness 91 Deafness, Autosomal Recessive, 91 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 91 Deafness, Autosomal Recessive, Type 91
Deafness, Autosomal Recessive 21	DFNB21 Autosomal Recessive Nonsyndromic Deafness 21 Autosomal Recessive Deafness 21 Deafness, Autosomal Recessive, 21 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 21 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 21 Deafness, Autosomal Recessive, Type 21
Deafness, Autosomal Recessive 49	DFNB49 Autosomal Recessive Nonsyndromic Deafness 49 Autosomal Recessive Deafness 49 Deafness, Autosomal Recessive, 49 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 49 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 49 Deafness, Autosomal Recessive, Type 49
Deafness, Autosomal Recessive 61	DFNB61 Autosomal Recessive Nonsyndromic Deafness 61 Autosomal Recessive Deafness 61 Deafness, Autosomal Recessive, 61 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61 Deafness, Autosomal Recessive, Type 61
Usher Syndrome, Type Iid	Usher Syndrome Type 2d USH2D Usher Syndrome, Type 2d Usher Syndrome Type Iid Usher Syndrome 2d Usher Syndrome, Type Ii
Superior Semicircular Canal Dehiscence	Superior Canal Dehiscence Syndrome Superior Semicircular Canal Dehiscence Syndrome Canal Dehiscence Syndrome Superior Canal Dehiscence Superior Canal Syndrome Third Mobile Window Syndrome Scds Anemia, Sickle Cell
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Deafness, Autosomal Recessive 63	DFNB63 Autosomal Recessive Nonsyndromic Deafness 63 Autosomal Recessive Deafness 63 Deafness, Autosomal Recessive, 63 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 63 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 63 Deafness, Autosomal Recessive, Type 63
Usher Syndrome, Type Iia	Usher Syndrome Type 2a USH2A Usher Syndrome, Type 2a Usher Syndrome Type Iia Retinal Disease In Usher Syndrome Type Iia, Modifier Of Us2 Ush2 Usher Syndrome 2a Usher'S Syndrome Type 2a Ushiia
Deafness, Autosomal Recessive 1a	DFNB1A Deafness, Digenic, Gjb2/Gjb3 Autosomal Recessive Nonsyndromic Deafness 1a Deafness, Digenic, Gjb2/Gjb6 Deafness, Digenic Gjb2/Gjb6 Autosomal Recessive Deafness 1a Deafness, Autosomal Recessive, 1a Deafness Digenic Gjb2/Gjb3 Deafness Digenic Gjb2/Gjb6 Deafness Neurosensory Autosomal Recessive 1 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 1 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 1 Nsrd1 Deafness, Autosomal Recessive, Type 1a
Deafness, Autosomal Recessive 12	DFNB12 Deafness, Autosomal Recessive 12, Modifier Of Autosomal Recessive Nonsyndromic Deafness 12 Autosomal Recessive Deafness 12 Deafness, Autosomal Recessive, 12 Congenital Neurosensory Deafness Autosomal Recessive 12 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12 Deafness, Autosomal Recessive, Type 12
Usher Syndrome Type 2	Ush2 Usher Syndrome Type Ii
Auditory System Disease	Ear Diseases Ear And Mastoid Disease
Autosomal Dominant Nonsyndromic Deafness	Autosomal Dominant Deafness
Usher Syndrome, Type I	USH1 Usher Syndrome Type 1 Us1 Usher Syndrome, Type 1b Usher Syndrome Type 1e Retinitis Pigmentosa And Congenital Deafness Usher Syndrome, Type Ie USH1E Usher Syndrome, Type 1e Usher Syndrome, Type 1a Usher Syndrome, Type Ib Usher Syndrome Type 1b Usher Syndrome Type Ie Usher Syndrome Type I Usher 1 Usher Syndrome, Type 1 Ush1a Usher Syndrome, Type I, French Variety Usher Syndrome, Type Ia Usher Syndrome 1b USH1B Usher'S Syndrome Type 1b Usher Syndrome Type Ib Ushib
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09860	OTOA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OTOA	VGNC	VGNC:75624
Bos taurus	OTOA	VGNC	VGNC:32483
Felis catus	OTOA	VGNC	VGNC:63993
Rattus norvegicus	OTOA	RGD	RGD:1562741
Mus musculus	OTOA	MGD	MGI:2149209
Canis familiaris	OTOA	VGNC	VGNC:44175
Others	OTOA	NCBI