ARSK - arylsulfatase family member K Gene

Also Known as MPS10; TSULF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153642

About ARSK

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,555,101-95,605,102 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues.

Summary

Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated Steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

ARSK Products (1)

mRNA Protein Name
NM_198150.3 NP_937793.1 arylsulfatase K precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arylsulfatase activity IMP
IMP: Inferred from mutant phenotype
23986440 GOA
enables glucuronate-2-sulfatase activity IMP
IMP: Inferred from mutant phenotype
28055182 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
23986440 GOA
located in lysosome IDA
IDA: Inferred from direct assay
23986440 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARSK Protein Structure

Sulfatase

Sulfatase: Sulfatase (32 - 370)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
Protein Preferred Names Protein Names

arylsulfatase K

  • ASK

Related Diseases

Diseases Alias
Mucopolysaccharidosis, Type X

  • MPS10

  • Arsk Deficiency

  • Arylsulfatase K Deficiency

  • Mucopolysaccharidosis 10

  • Arlysulfatase K Deficiency

  • Mucopolysaccharidosis, Type 10
Gastric Dilatation

  • Stomach Dilatation
Metachromatic Leukodystrophy

  • Arylsulfatase A Deficiency

  • MLD

  • Arsa Deficiency

  • Sulfatide Lipidosis

  • Metachromatic Leukoencephalopathy

  • Cerebral Sclerosis, Diffuse, Metachromatic Form

  • Cerebroside Sulfatase Deficiency

  • Leukodystrophy, Metachromatic

  • Pseudoarylsulfatase A Deficiency

  • Leukodystrophy Metachromatic

  • Sulfatidosis

  • Metachromatic Leukodystrophy, Late Infantile

  • Metachromatic Leukodystrophy Variant

  • Deficiency Of Cerebroside-Sulfatase

  • Scholz Cerebral Sclerosis

  • Sulfatide Lipoidosis

  • Cerebral Sclerosis Diffuse Metachromatic Form

  • Arylsulfatase A Deficiency Disease

  • Cerebroside Sulphatase Deficiency Disease

  • Greenfield Disease

  • Metachromatic Leukodystrophy, Adult

  • Metachromatic Leukodystrophy, Juvenile

  • Leukodystrophy Metachromatic Adult

  • Leukodystrophy Metachromatic Juvenile

  • Leukodystrophy Metachromatic Late Infantile

  • Metachromatic Leukodystrophy, Adult Type

  • Metachromatic Leukodystrophy, Juvenile Type

  • Metachromatic Leukodystrophy, Infant

  • Greenfield'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01042 ARSK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARSK MGD MGI:1924291
Bos taurus ARSK VGNC VGNC:26179
Macaca mulatta ARSK VGNC VGNC:84280
Canis familiaris ARSK VGNC VGNC:38146
Felis catus ARSK VGNC VGNC:59949
Rattus norvegicus ARSK RGD RGD:1310182
Others ARSK NCBI