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THAP5 - THAP domain containing 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 168451

About THAP5

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:108,541,759-108,569,768 (from NCBI)

This gene has 8 transcripts (splice variants) and 103 orthologues. Ubiquitous expression in thyroid (RPKM 13.7), testis (RPKM 10.7) and 25 other tissues.

Summary

Enables protease binding activity. Involved in negative regulation of cell cycle and negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

THAP5 Products (5)

mRNA	Protein	Name
NM_001130475.3	NP_001123947.1	THAP domain-containing protein 5 isoform 1
NM_001287598.1	NP_001274527.1	THAP domain-containing protein 5 isoform 3
NM_001287599.1	NP_001274528.1	THAP domain-containing protein 5 isoform 3
NM_001287601.1	NP_001274530.1	THAP domain-containing protein 5 isoform 3
NM_182529.3	NP_872335.2	THAP domain-containing protein 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protease binding	IPI IPI: Inferred from physical interaction	19502560	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19502560	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21110952	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	21110952	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19502560	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP5 Protein Structure

THAP

0
100
200
300
395 a.a.

Protein Preferred Names	Protein Names
THAP domain-containing protein 5

Related Diseases

Diseases	Alias
Townes-Brocks Syndrome	Townes Syndrome Renal-Ear-Anal-Radial Syndrome Anus, Imperforate, With Hand, Foot And Ear Anomalies Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome Rear Syndrome Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs Tbs Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs Imperforate Anus With Hand, Foot And Ear Anomalies Anal-Ear-Renal-Radial Malformation Syndrome Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Imperforate Anus-Hand And Foot Anomalies Syndrome Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14476	THAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown