CELSR3 - cadherin EGF LAG seven-pass G-type receptor 3 Gene

Homo sapiens

Also known as FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1

Gene ID: 1951 | Gene type: protein coding

About CELSR3

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,636,463-48,662,886 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 6 paralogues. Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 17 other tissues.

Summary

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo Cadherins consist of nonclassic-type Cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

CELSR3 Products(1)

mRNA	Protein	Name
NM_001407.3	NP_001398.2	cadherin EGF LAG seven-pass G-type receptor 3 precursor

CELSR3 Protein Structure

Cadherin

EGF

Laminin_G_2

EGF

Laminin_G_2

Laminin_EGF

HRM

GPS

7tm_2

0
600
1200
1800
2400
3000
3312 a.a.

Protein Preferred Names

Protein Names

cadherin EGF LAG seven-pass G-type receptor 3

EGF-like protein 1

Related Diseases

Diseases

Alias

Autosomal Dominant Wolfram Syndrome

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Bjornstad Syndrome

BJS	Pili Torti And Nerve Deafness
Ptd	Pili Torti-Deafness Syndrome
Deafness-Pili Torti-Hypogonadism Syndrome	Deafness And Pili Torti, Bjornstad Type
Pili Torti-Sensorineural Hearing Loss	Björnstad Syndrome
Ptnd	Hearing Loss-Pili Torti-Hypogonadism Syndrome
Bjoernstad Syndrome

Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex	Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex
Beec	Eec
Exstrophy Of The Bladder	Bladder Exstrophy
Bladder Exstrophy And Epispadias Complex

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Tic Disorder

Tics	Behavioral Tic

Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02467	CELSR3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CELSR3	MGD	MGI:1858236
Canis familiaris	CELSR3	VGNC	VGNC:54589
Bos taurus	CELSR3	VGNC	VGNC:27171
Macaca mulatta	CELSR3	VGNC	VGNC:71148
Rattus norvegicus	CELSR3	RGD	RGD:621787
Felis catus	CELSR3	VGNC	VGNC:82466
Others	CELSR3	NCBI

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