LCTL - lactase like Gene

Also Known as KLG; KLPH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 197021

About LCTL

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,547,532-66,565,998 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 4 paralogues. Broad expression in testis (RPKM 4.1), lymph node (RPKM 0.7) and 20 other tissues.

Summary

This gene encodes a member of family 1 glycosidases. Glycosidases are Enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, Glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

LCTL Products (4)

mRNA	Protein	Name
NM_001278562.3	NP_001265491.1	lactase-like protein isoform 2
NM_001394632.1	NP_001381561.1	lactase-like protein isoform 3
NM_001394633.1	NP_001381562.1	lactase-like protein isoform 4
NM_207338.4	NP_997221.2	lactase-like protein isoform 1 precursor

LCTL Protein Structure

Glyco_hydro_1

0
100
200
300
400
500
567 a.a.

Protein Preferred Names	Protein Names
lactase-like protein	KL lactase phlorizin hydrolase

Related Diseases

Diseases	Alias
Metacarpal 4-5 Fusion	Syndactyly Type 8 MF4 Fusion Of Metacarpals 4 And 5 Metacarpals 4 And 5 Fusion Metacarpal 4 5 Fusion
Presbyopia	Subnormal Accommodation Accommodation Insufficiency Of Old Age
Brooke-Spiegler Syndrome	Cyld Cutaneous Syndrome Spiegler-Brooke Syndrome Familial Cylindromatosis BRSS Bss Sbs Multiple Familial Trichoepithelioma Ancell-Spiegler Cylindromas Familial Multiple Trichoepithelioma Trichoepithelioma Fc Mft Multiple Familial Trichoepitheliomas Ccs Turban Tumor Syndrome Schilbach-Rott Syndrome Eccrine Dermal Cylindroma Familial Multiple Trichoepitheliomata

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07566	LCTL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LCTL	VGNC	VGNC:74049
Rattus norvegicus	LCTL	RGD	RGD:1305177
Bos taurus	LCTL	VGNC	VGNC:30820
Mus musculus	LCTL	MGD	MGI:2183549
Canis familiaris	LCTL	VGNC	VGNC:58312
Felis catus	LCTL	VGNC	VGNC:63206