NLRP11 - NLR family pyrin domain containing 11 Gene

Also Known as NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 204801

About NLRP11

Cytogenetic location: 19q13.42-q13.43 Genomic coordinates (GRCh38): 19:55,785,399-55,836,575 (from NCBI)

This gene has 6 transcripts (splice variants), 36 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the the NOD-like Receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of Other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

NLRP11 Products (5)

mRNA Protein Name
NM_001297743.3 NP_001284672.1 NACHT, LRR and PYD domains-containing protein 11 isoform 2
NM_001385451.2 NP_001372380.1 NACHT, LRR and PYD domains-containing protein 11 isoform 3
NM_001385453.2 NP_001372382.1 NACHT, LRR and PYD domains-containing protein 11 isoform 4
NM_001394894.2 NP_001381823.1 NACHT, LRR and PYD domains-containing protein 11 isoform 1
NM_145007.5 NP_659444.2 NACHT, LRR and PYD domains-containing protein 11 isoform 1

NLRP11 Protein Structure

PYRIN

PYRIN: PAAD/DAPIN/Pyrin domain (8 - 85)

NACHT

NACHT: NACHT domain (149 - 315)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1033 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 11

  • NACHT, leucine rich repeat and PYD containing 11

Related Diseases

Diseases Alias
Petrositis

  • Acute Petrositis

  • Chronic Petrositis

  • Inflammation Of Petrous Bone

  • Osteitis Of Petrous Bone

  • Osteomyelitis Of Petrous Bone
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09351 NLRP11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown