Nlgn2 - neuroligin 2 Gene

Also Known as NL2; NLG2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216856

Summary

Enables cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synapse organization. Acts upstream of or within several processes, including GABAergic synaptic transmission; protein localization to cell surface; and regulation of respiratory gaseous exchange by nervous system process. Located in GABA-ergic synapse; cell surface; and dopaminergic synapse. Is active in glycinergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in brainstem. Used to study schizophrenia. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn2 Products (2)

mRNA Protein Name
NM_001364137.1 NP_001351066.1 neuroligin-2 precursor
NM_198862.2 NP_942562.2 neuroligin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
21424692 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
18250328 MGI
enables neurexin family protein binding IPI
IPI: Inferred from physical interaction
21424692 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19816407 MGI
Biological Process GO Annotation Evidence References Source
involved in gephyrin clustering involved in postsynaptic density assembly IDA
IDA: Inferred from direct assay
15620359 MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly IGI
IGI: Inferred from genetic interaction
29107521 MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
29107521 MGI
involved in inhibitory synapse assembly IDA
IDA: Inferred from direct assay
22960622 MGI
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
19016888 MGI
acts upstream of or within modulation of chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
16982420 MGI
involved in neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
19016888 MGI
acts upstream of or within neurotransmitter-gated ion channel clustering IDA
IDA: Inferred from direct assay
29107521 MGI
acts upstream of or within neurotransmitter-gated ion channel clustering IGI
IGI: Inferred from genetic interaction
29107521 MGI
acts upstream of or within neurotransmitter-gated ion channel clustering IMP
IMP: Inferred from mutant phenotype
29107521 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
15620359 MGI
involved in positive regulation of inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
15620359 MGI
involved in positive regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
15620359 MGI
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15620359 MGI
involved in positive regulation of synaptic vesicle clustering IDA
IDA: Inferred from direct assay
15620359 MGI
involved in postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
15620359 MGI
involved in postsynaptic membrane assembly IDA
IDA: Inferred from direct assay
15620359 MGI
involved in postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
15620359 MGI
involved in postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
15620359 MGI
acts upstream of or within presynapse assembly IDA
IDA: Inferred from direct assay
23358245 MGI
involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
15620359 MGI
involved in presynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
19016888 MGI
acts upstream of or within protein localization to cell surface IDA
IDA: Inferred from direct assay
29107521 MGI
acts upstream of or within protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
29107521 MGI
involved in protein localization to synapse IDA
IDA: Inferred from direct assay
15620359 MGI
involved in regulation of AMPA receptor activity IMP
IMP: Inferred from mutant phenotype
15620359 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IGI
IGI: Inferred from genetic interaction
16982420 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
19016888 MGI
acts upstream of or within synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
29107521 MGI
acts upstream of or within synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
29107521 MGI
acts upstream of or within synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
29107521 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
15620359 MGI
located in GABA-ergic synapse IDA
IDA: Inferred from direct assay
29107521 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
15620359 MGI
is active in axon IDA
IDA: Inferred from direct assay
23358245 MGI
is active in cell surface IDA
IDA: Inferred from direct assay
23358245 MGI
located in cell surface IDA
IDA: Inferred from direct assay
29107521 MGI
is active in dendrite IDA
IDA: Inferred from direct assay
23358245 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
27035941 MGI
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
19755106 MGI
is active in glycinergic synapse IMP
IMP: Inferred from mutant phenotype
19755106 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
27035941 MGI
located in synapse IDA
IDA: Inferred from direct assay
15681343 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroligin-2

  • ortholog of human and rat neuroligin 2 NLGN2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09340 NLGN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22679 Nlgn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29193 Nlgn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlgn2 NCBI NCBI:57555