PIK3R5 - phosphoinositide-3-kinase regulatory subunit 5 Gene

Homo sapiens

Also known as p101; FOAP-2; P101-PI3K; F730038I15Rik

Gene ID: 23533 | Gene type: protein coding

About PIK3R5

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,878,916-8,965,707 (from NCBI)

This gene has 19 transcripts (splice variants), 255 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 25.8), spleen (RPKM 14.1) and 13 other tissues.

Summary

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric Enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

PIK3R5 Products(11)

mRNA	Protein	Name
NM_001142633.3	NP_001136105.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 1
NM_001251851.2	NP_001238780.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001251852.2	NP_001238781.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001251853.2	NP_001238782.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001251855.2	NP_001238784.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001388396.1	NP_001375325.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 4
NM_001388397.1	NP_001375326.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001388398.1	NP_001375327.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001388399.1	NP_001375328.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NM_001388400.1	NP_001375329.1	phosphoinositide 3-kinase regulatory subunit 5 isoform 3
NM_014308.4	NP_055123.2	phosphoinositide 3-kinase regulatory subunit 5 isoform 1

PIK3R5 Protein Structure

PI3K_1B_p101

0
200
400
600
800
880 a.a.

Protein Preferred Names

Protein Names

phosphoinositide 3-kinase regulatory subunit 5

PI3-kinase p101 subunit

Related Diseases

Diseases

Alias

Ataxia-Oculomotor Apraxia 3

Ataxia With Oculomotor Apraxia Type 3	AOA3
Aaxia-Oculomotor Apraxia-3	Ataxia-Oculomotor Apraxia, Type 3

Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2

Aoa2	Ataxia With Oculomotor Apraxia Type 2
Scar1	SCAN2
Ataxia-Oculomotor Apraxia 2	Ataxia-Ocular Apraxia 2
Ataxia-Oculomotor Apraxia Type 2	Scan 2
Spinocerebellar Ataxia With Axonal Neuropathy Type 2	Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly
Scar1, Formerly	Autosomal Recessive Spinocerebellar Ataxia-1
Spinocerebellar Ataxia, Autosomal Recessive, 1	Ataxia-Ocular Apraxia-2
Spinocerebellar Ataxia, Autosomal Recessive 1

Apraxia

Apraxias

Dyspraxia

Oculomotor Apraxia

Spinocerebellar Ataxia, Autosomal Recessive 26

SCAR26	Autosomal Recessive Spinocerebellar Ataxia 26
Spinocerebellar Ataxia, Autosomal Recessive, 26

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10540	PIK3R5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIK3R5	MGD	MGI:2443588
Canis familiaris	PIK3R5	VGNC	VGNC:44562
Felis catus	PIK3R5	VGNC	VGNC:99317
Bos taurus	PIK3R5	VGNC	VGNC:32896
Rattus norvegicus	PIK3R5	RGD	RGD:1563261
Macaca mulatta	PIK3R5	VGNC	VGNC:75892

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