Rgs7 - regulator of G protein signaling 7 Gene

Mus musculus

Gene ID: 24012 | Gene type: protein coding

About Rgs7

Summary

Predicted to enable G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in regulation of postsynaptic membrane potential. Acts upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Located in several cellular components, including dendrite terminus; glutamatergic synapse; and nucleus. Is active in postsynaptic membrane and presynapse. Is expressed in bone; foot mesenchyme; nervous system; pelvic girdle skeleton; and sensory organ. Orthologous to human RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Apr 2022]

Rgs7 Products(4)

mRNA	Protein	Name
NM_001199003.1	NP_001185932.1	regulator of G-protein signaling 7 isoform 2
NM_001347195.1	NP_001334124.1	regulator of G-protein signaling 7 isoform 3
NM_001357129.1	NP_001344058.1	regulator of G-protein signaling 7 isoform 4
NM_011880.3	NP_036010.2	regulator of G-protein signaling 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	25792749	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15897264	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15897264	MGI
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	25792749	MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22689652	MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22689652	MGI
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	24755289	MGI
involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	24755289	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell tip	IDA IDA: Inferred from direct assay	25997951	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	25997951	MGI
located in dendrite terminus	IDA IDA: Inferred from direct assay	22689652	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24755289	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24755289	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15897264	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15897264	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	23804514	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	27965545	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	23804514	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulator of G-protein signaling 7

Regulator of G-protein signaling 7 (RGS7)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11925	RGS7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs7	NCBI	NCBI:6000

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