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Taf10 - TATA-box binding protein associated factor 10 Gene

Also Known as 30kDa; Taf2h; TAFII30

Species: Mus musculus

Gene Type: protein coding

Gene ID: 24075

Summary

Enables DNA binding activity and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; hepatocyte differentiation; and regulation of DNA binding activity. Located in nucleus. Is expressed in several structures, including blastocyst; embryo mesenchyme; gut; nervous system; and sensory organ epithelium. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Taf10 Products (1)

mRNA	Protein	Name
NM_020024.3	NP_064408.2	transcription initiation factor TFIID subunit 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18722179	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22323595	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22323595	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10469660	MGI
involved in RNA polymerase II preinitiation complex assembly	IMP IMP: Inferred from mutant phenotype	28893950	MGI
involved in SAGA complex assembly	IMP IMP: Inferred from mutant phenotype	28893950	MGI
involved in allantois development	IMP IMP: Inferred from mutant phenotype	28893950	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	10469660	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	18722179	MGI
involved in embryonic placenta development	IMP IMP: Inferred from mutant phenotype	28893950	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	28893950	MGI
acts upstream of or within hepatocyte differentiation	IMP IMP: Inferred from mutant phenotype	18722179	MGI
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	28893950	MGI
involved in lateral mesodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	28893950	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	28893950	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	18722179	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	22323595	MGI
involved in multicellular organism growth	IMP IMP: Inferred from mutant phenotype	28893950	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	18722179	MGI
acts upstream of or within regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	18722179	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18722179	MGI
involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	28893950	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	12665565	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	28893950	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18722179	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	22323595	MGI
part of transcription preinitiation complex	IDA IDA: Inferred from direct assay	28893950	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 10	TAF(II)30 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kDa TAFII-30 TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30 kDa mTAFII30 transcription initiation factor TFIID 30 kDa subunit

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14158	TAF10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Taf10	NCBI	NCBI:6881