IFIT5 - interferon induced protein with tetratricopeptide repeats 5 Gene

Homo sapiens

Also known as P58; RI58; ISG58

Gene ID: 24138 | Gene type: protein coding

About IFIT5

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,414,568-89,420,997 (from NCBI)

This gene has 8 transcripts (splice variants), 527 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues.

Summary

Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

IFIT5 Products(1)

mRNA	Protein	Name
NM_012420.3	NP_036552.1	interferon-induced protein with tetratricopeptide repeats 5

IFIT5 Protein Structure

TPR_12

TPR_2

TPR_11

TPR_1

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

interferon-induced protein with tetratricopeptide repeats 5

IFIT-5

Related Diseases

Diseases

Alias

Zika Virus Congenital Syndrome

Zikv Congenital Infection

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06564	IFIT5 Human Pre-designed siRNA Set A		/	Unkown

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