Xirp2 - xin actin-binding repeat containing 2 Gene

Mus musculus

Also known as Xin2; Cmya3; Gm352; 2310003D02Rik; 2310008C07Rik; A530024P18Rik

Gene ID: 241431 | Gene type: protein coding

About Xirp2

Summary

Enables alpha-actinin binding activity. Acts upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in Z disc. Is expressed in heart; lung; and skeletal muscle. Orthologous to human XIRP2 (xin actin binding repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Xirp2 Products(2)

mRNA	Protein	Name
NM_001024618.2	NP_001019789.1	xin actin-binding repeat-containing protein 2 isoform 1
NM_001083919.1	NP_001077388.1	xin actin-binding repeat-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-actinin binding	IDA IDA: Inferred from direct assay	17046827	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21689717	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	20360251	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	20360251	MGI
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	37294664	MGI
involved in regulation of actin filament organization	IMP IMP: Inferred from mutant phenotype	25772365	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	20360251	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	17046827	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	37294664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

xin actin-binding repeat-containing protein 2

Xin actin-binding repeat containing 2 short splice form	beta-xin
cardiomyopathy associated 3	cardiomyopathy-associated protein 3
mXinbeta	myogenic MEF2-activated Xin-related protein
myomaxin	xeplin
xin-beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15877	XIRP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xirp2	NCBI	NCBI:129446

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