Fermt1 - fermitin family member 1 Gene

Also Known as Kindlin-1; 5830467P10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 241639

Summary

Enables actin filament binding activity. Involved in several processes, including positive regulation of cell adhesion; regulation of gene expression; and regulation of signal transduction. Located in focal adhesion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study Kindler syndrome. Human ortholog(s) of this gene implicated in Kindler syndrome; telangiectasis; and vesiculobullous skin disease. Orthologous to human FERMT1 (FERM domain containing kindlin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fermt1 Products (1)

mRNA Protein Name
NM_198029.2 NP_932146.2 fermitin family homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
16876785 MGI
Biological Process GO Annotation Evidence References Source
involved in basement membrane organization IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in negative regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in negative regulation of timing of anagen IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in positive regulation of cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in positive regulation of transforming growth factor beta production IMP
IMP: Inferred from mutant phenotype
24681597 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24681597 MGI
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
16876785 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fermitin family homolog 1

  • unc-112-related protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04864 FERMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21129 Fermt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27647 Fermt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fermt1 NCBI NCBI:55612