Atp1a3 - ATPase Na+/K+ transporting subunit alpha 3 Gene

Rattus norvegicus

Also known as Atpa1a3

Gene ID: 24213 | Gene type: protein coding

About Atp1a3

Summary

Enables D1 Dopamine Receptor binding activity and amyloid-beta binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to retinoic acid; and metal ion transport. Located in several cellular components, including axon; dendritic spine; and myelin sheath. Part of sodium:potassium-exchanging ATPase complex. Is active in calyx of Held and postsynapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a3 Products(1)

mRNA	Protein	Name
NM_012506.1	NP_036638.1	sodium/potassium-transporting ATPase subunit alpha-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	21809413	RGD
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	26224839	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	26224839	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12093728	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	26224839	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	8944660	RGD
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	8944660	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	19362129	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	12617948	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	17220883	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	21809413	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	21809413	RGD
located in membrane	IDA IDA: Inferred from direct assay	26224839	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	19082858	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	17220883	RGD
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	12093728	RGD
located in synapse	IDA IDA: Inferred from direct assay	16630822	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit alpha-3

ATPase, Na+/K+ transporting, alpha 3 polypeptide	ATPase, Na+K+ transporting, alpha 3 subunit
NA,K-ATPase alpha subunit 3	Na(+)/K(+) ATPase alpha(III) subunit
Na(+)/K(+) ATPase alpha-3 subunit	Na+/K+ -ATPase alpha 3 subunit
sodium pump subunit alpha-

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01188	ATP1B3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01184	ATP1A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a3	NCBI	NCBI:478

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