Atp1a3 - ATPase Na+/K+ transporting subunit alpha 3 Gene

Also Known as Atpa1a3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24213

Summary

Enables D1 Dopamine Receptor binding activity and amyloid-beta binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to retinoic acid; and metal ion transport. Located in several cellular components, including axon; dendritic spine; and myelin sheath. Part of sodium:potassium-exchanging ATPase complex. Is active in calyx of Held and postsynapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a3 Products (1)

mRNA Protein Name
NM_012506.1 NP_036638.1 sodium/potassium-transporting ATPase subunit alpha-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
21809413 RGD
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
26224839 RGD
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
26224839 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12093728 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IDA
IDA: Inferred from direct assay
26224839 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
8944660 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: Inferred from expression pattern
8944660 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
19362129 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
12093728 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
12093728 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12617948 RGD
is active in calyx of Held IDA
IDA: Inferred from direct assay
17220883 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
21809413 RGD
located in dendritic spine neck IDA
IDA: Inferred from direct assay
21809413 RGD
located in membrane IDA
IDA: Inferred from direct assay
26224839 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
19082858 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
17220883 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: Inferred from direct assay
12093728 RGD
located in synapse IDA
IDA: Inferred from direct assay
16630822 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium-transporting ATPase subunit alpha-3

  • ATPase, Na+/K+ transporting, alpha 3 polypeptide

  • ATPase, Na+K+ transporting, alpha 3 subunit

  • NA,K-ATPase alpha subunit 3

  • Na(+)/K(+) ATPase alpha(III) subunit

  • Na(+)/K(+) ATPase alpha-3 subunit

  • Na+/K+ -ATPase alpha 3 subunit

  • sodium pump subunit alpha-

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01188 ATP1B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01184 ATP1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp1a3 NCBI NCBI:478