2. Gene
  3. Chrnb1 - cholinergic receptor nicotinic beta 1 subunit Gene

Chrnb1 - cholinergic receptor nicotinic beta 1 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Acrb; nAChR; RNACRB1

Gene ID: 24261 | Gene type: protein coding

About Chrnb1

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb1 Products(2)

mRNA Protein Name
NM_001395118.1 NP_001382047.1 acetylcholine receptor subunit beta isoform 1 precursor
NM_012528.2 NP_036660.1 acetylcholine receptor subunit beta isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: Inferred from direct assay
1702709 RGD
enables ligand-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
1702709 RGD
Biological Process GO Annotation Evidence Reference Source
involved in monoatomic cation transport IDA
IDA: Inferred from direct assay
22461452 RGD
involved in skeletal muscle contraction IDA
IDA: Inferred from direct assay
22461452 RGD
Cellular Component GO Annotation Evidence Reference Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
22461452 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetylcholine receptor subunit beta

Acetylcholine receptor beta

cholinergic receptor nicotinic beta polypeptide 1

cholinergic receptor, nicotinic beta 1

cholinergic receptor, nicotinic, beta 1 (muscle)

cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)

n acetylcholine recepto

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02674 CHRNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrnb1 NCBI NCBI:1140