Wasf2 - WASP family, member 2 Gene

Also Known as WAVE2; D4Ertd13e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 242687

Summary

Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Involved in postsynaptic actin Cytoskeleton organization. Acts upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Located in several cellular components, including early endosome; lamellipodium; and ruffle. Part of SCAR complex. Is active in synapse. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; heart; and yolk sac. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Wasf2 Products (1)

mRNA Protein Name
NM_153423.6 NP_700472.1 actin-binding protein WASF2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
12853475 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12853475 MGI
acts upstream of or within actin filament-based movement IMP
IMP: Inferred from mutant phenotype
12853475 MGI
acts upstream of or within ameboidal-type cell migration IMP
IMP: Inferred from mutant phenotype
12879075 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12879075 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
12853475 MGI
acts upstream of or within endocytosis IDA
IDA: Inferred from direct assay
12446704 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
12879075 MGI
acts upstream of or within lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
17664349 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
17664349 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
15673667 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
15673667 MGI
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
15673667 MGI
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15673667 MGI
Cellular Component GO Annotation Evidence References Source
part of SCAR complex IDA
IDA: Inferred from direct assay
26428302 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in early endosome IDA
IDA: Inferred from direct assay
12446704 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
17664349 MGI
located in ruffle IDA
IDA: Inferred from direct assay
12446704 MGI
is active in synapse EXP
EXP: Inferred from Experiment
28252024 MGI
is active in synapse IDA
IDA: Inferred from direct assay
28252024 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-binding protein WASF2

wiskott-Aldrich syndrome protein family member 2

  • WAS protein family, member 2

  • WASP family protein member 2

  • protein WAVE-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15743 WASF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasf2 NCBI NCBI:10163