Wasf2 - WASP family, member 2 Gene

Mus musculus

Also known as WAVE2; D4Ertd13e

Gene ID: 242687 | Gene type: protein coding

About Wasf2

Summary

Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Involved in postsynaptic actin Cytoskeleton organization. Acts upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Located in several cellular components, including early endosome; lamellipodium; and ruffle. Part of SCAR complex. Is active in synapse. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; heart; and yolk sac. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Wasf2 Products(1)

mRNA	Protein	Name
NM_153423.6	NP_700472.1	actin-binding protein WASF2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	12853475	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12853475	MGI
acts upstream of or within actin filament-based movement	IMP IMP: Inferred from mutant phenotype	12853475	MGI
acts upstream of or within ameboidal-type cell migration	IMP IMP: Inferred from mutant phenotype	12879075	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12879075	MGI
acts upstream of or within cell motility	IMP IMP: Inferred from mutant phenotype	12853475	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	12446704	MGI
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	12879075	MGI
acts upstream of or within lamellipodium morphogenesis	IMP IMP: Inferred from mutant phenotype	17664349	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	17664349	MGI
involved in postsynapse organization	IDA IDA: Inferred from direct assay	15673667	MGI
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	15673667	MGI
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15673667	MGI
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15673667	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCAR complex	IDA IDA: Inferred from direct assay	26428302	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in early endosome	IDA IDA: Inferred from direct assay	12446704	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	17664349	MGI
located in ruffle	IDA IDA: Inferred from direct assay	12446704	MGI
is active in synapse	EXP EXP: Inferred from Experiment	28252024	MGI
is active in synapse	IDA IDA: Inferred from direct assay	28252024	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin-binding protein WASF2

wiskott-Aldrich syndrome protein family member 2

WAS protein family, member 2	WASP family protein member 2
protein WAVE-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15743	WASF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wasf2	NCBI	NCBI:10163

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