Prickle2 - prickle planar cell polarity protein 2 Gene

Mus musculus

Also known as Pk2; mpk2; 6230400G14Rik; 6720451F06Rik

Gene ID: 243548 | Gene type: protein coding

About Prickle2

Summary

Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including establishment or maintenance of epithelial cell apical/basal polarity; neuron projection development; and trophectodermal cell fate commitment. Located in several cellular components, including apicolateral plasma membrane; lateral plasma membrane; and nucleus. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; notochord; and primitive streak. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Prickle2 Products(5)

mRNA	Protein	Name
NM_001081146.3	NP_001074615.1	prickle-like protein 2 isoform a
NM_001134459.2	NP_001127931.1	prickle-like protein 2 isoform b
NM_001134460.3	NP_001127932.1	prickle-like protein 2 isoform b
NM_001134461.2	NP_001127933.1	prickle-like protein 2 isoform b
NM_001404086.1	NP_001391015.1	prickle-like protein 2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19788910	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in embryonic brain development	IMP IMP: Inferred from mutant phenotype	17868671	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	17376975	MGI
involved in maintenance of postsynaptic density structure	IDA IDA: Inferred from direct assay	34613779	MGI
involved in maintenance of postsynaptic density structure	IMP IMP: Inferred from mutant phenotype	34613779	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	19788910	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	17868671	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	23711981	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	23711981	MGI
involved in response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	21276947	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	17376975	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22333836	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23711981	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23711981	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	17376975	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21324980	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	21324980	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prickle-like protein 2

prickle homolog 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11094	PRICKLE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prickle2	NCBI	NCBI:166336

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