Iqsec3 - IQ motif and Sec7 domain 3 Gene

Also Known as BRAG3; mKIAA1110; synarfGEF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 243621

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including actin Cytoskeleton organization; activation of GTPase activity; and regulation of small GTPase mediated signal transduction. Located in inhibitory synapse; postsynaptic density; and postsynaptic membrane. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization of symmetric synapse. Is expressed in endocrine gland; nervous system; and testis. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Apr 2022]

Iqsec3 Products (4)

mRNA Protein Name
NM_001033354.4 NP_001028526.1 IQ motif and SEC7 domain-containing protein 3 isoform 1
NM_001289685.2 NP_001276614.1 IQ motif and SEC7 domain-containing protein 3 isoform 2
NM_001411678.1 NP_001398607.1 IQ motif and SEC7 domain-containing protein 3 isoform 3
NM_001411679.1 NP_001398608.1 IQ motif and SEC7 domain-containing protein 3 isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21198641 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
21198641 MGI
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
21198641 MGI
located in inhibitory synapse IDA
IDA: Inferred from direct assay
21198641 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
27609886 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
21198641 MGI
is active in postsynaptic specialization of symmetric synapse IDA
IDA: Inferred from direct assay
21198641 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

IQ motif and SEC7 domain-containing protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06890 IQSEC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iqsec3 NCBI NCBI:440073