Shank1 - SH3 and multiple ankyrin repeat domains 1 Gene

Mus musculus

Gene ID: 243961 | Gene type: protein coding

About Shank1

Summary

Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Shank1 Products(1)

mRNA	Protein	Name
NM_001034115.1	NP_001029287.1	SH3 and multiple ankyrin repeat domains protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	18272690	MGI
enables structural constituent of postsynaptic density	IEP IEP: Inferred from expression pattern	18272690	MGI
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	18272690	MGI
enables synaptic receptor adaptor activity	IMP IMP: Inferred from mutant phenotype	18272690	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in associative learning	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in habituation	IMP IMP: Inferred from mutant phenotype	21695253	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	18272690	MGI
involved in modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	18272690	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18272690	MGI
acts upstream of or within negative regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	19208628	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	20868654	MGI
involved in olfactory behavior	IMP IMP: Inferred from mutant phenotype	21695253	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in protein localization to synapse	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	18272690	MGI
involved in righting reflex	IMP IMP: Inferred from mutant phenotype	21695253	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21695253	MGI
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	21695253	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18272690	MGI
is active in Schaffer collateral - CA1 synapse	IEP IEP: Inferred from expression pattern	18272690	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18272690	MGI
located in dendrite	IDA IDA: Inferred from direct assay	21940441	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	15207857	MGI
located in excitatory synapse	IDA IDA: Inferred from direct assay	18272690	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18272690	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	18272690	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18272690	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15207857	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	18272690	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	18272690	MGI
colocalizes with postsynaptic membrane	IDA IDA: Inferred from direct assay	15207857	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15950311	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH3 and multiple ankyrin repeat domains protein 1

SH3/ankyrin domain gene 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12850	SHANK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shank1	NCBI	NCBI:50944

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