Shank1 - SH3 and multiple ankyrin repeat domains 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 243961

Summary

Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Shank1 Products (1)

mRNA Protein Name
NM_001034115.1 NP_001029287.1 SH3 and multiple ankyrin repeat domains protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
15207857 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15207857 MGI
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
18272690 MGI
enables structural constituent of postsynaptic density IEP
IEP: Inferred from expression pattern
18272690 MGI
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
18272690 MGI
enables synaptic receptor adaptor activity IMP
IMP: Inferred from mutant phenotype
18272690 MGI
Biological Process GO Annotation Evidence References Source
involved in associative learning IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in habituation IMP
IMP: Inferred from mutant phenotype
21695253 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
18272690 MGI
involved in modulation of chemical synaptic transmission IEP
IEP: Inferred from expression pattern
18272690 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
18272690 MGI
acts upstream of or within negative regulation of actin filament bundle assembly IDA
IDA: Inferred from direct assay
19208628 MGI
involved in neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
20868654 MGI
involved in olfactory behavior IMP
IMP: Inferred from mutant phenotype
21695253 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in protein localization to synapse IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in regulation of AMPA receptor activity IMP
IMP: Inferred from mutant phenotype
18272690 MGI
involved in righting reflex IMP
IMP: Inferred from mutant phenotype
21695253 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
21695253 MGI
involved in vocalization behavior IMP
IMP: Inferred from mutant phenotype
21695253 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
18272690 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
18272690 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
18272690 MGI
located in dendrite IDA
IDA: Inferred from direct assay
21940441 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
15207857 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
18272690 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18272690 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
18272690 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18272690 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21795692 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15207857 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
18272690 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
18272690 MGI
colocalizes with postsynaptic membrane IDA
IDA: Inferred from direct assay
15207857 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15950311 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH3 and multiple ankyrin repeat domains protein 1

  • SH3/ankyrin domain gene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12850 SHANK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shank1 NCBI NCBI:50944