2. Gene
  3. Dclk3 - doublecortin-like kinase 3 Gene

Dclk3 - doublecortin-like kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dcamkl3; C730036H08

Gene ID: 245038 | Gene type: protein coding

About Dclk3

Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the Other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]

Dclk3 Products(1)

mRNA Protein Name
NM_172928.5 NP_766516.2 serine/threonine-protein kinase DCLK3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
29534157 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
16684769 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
16684769 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
16684769 MGI
acts upstream of protein localization to nucleus IDA
IDA: Inferred from direct assay
16684769 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16684769 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16684769 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase DCLK3

CLICK-I and II-related

CLr

Click-I, -II related

doublecortin and CaM kinase-like 3

doublecortin-like and CAM kinase-like 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03580 DCLK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dclk3 NCBI NCBI:85443